Mouse Anti-CALCB Recombinant Antibody (CBLC061-LY) (CBMAB-C9639-LY)

The product is antibody recognizes CALCB. The antibody CBLC061-LY immunoassay techniques such as: WB, ICC, IHC-P, IHC-F, ELISA.
See all CALCB antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Rat

Clone

CBLC061-LY

Antibody Isotype

IgG

Application

WB, ICC, IHC-P, IHC-F, ELISA

Basic Information

Specificity

Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

50% glycerol

Preservative

0.02% NaN3

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Calcitonin Related Polypeptide Beta

Introduction

CALCB (Calcitonin Related Polypeptide Beta) is a Protein Coding gene. Diseases associated with CALCB include Thyroid Carcinoma, Familial Medullary. Among its related pathways are Peptide ligand-binding receptors and Presynaptic function of Kainate receptors. Gene Ontology (GO) annotations related to this gene include hormone activity and neuropeptide hormone activity. An important paralog of this gene is CALCA.

Entrez Gene ID

171519

UniProt ID

P10093

Function

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Cellular calcium ion homeostasis Source: ProtInc
G protein-coupled receptor signaling pathway Source: Reactome
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Regulation of cytosolic calcium ion concentration Source: GO_Central
Signal transduction Source: ProtInc

Cellular Location

Secreted

References

Dai, C., Zhang, B., Liao, Y., Liu, Q., Wu, F., Lv, X., ... & Zhu, X. (2021). CALCB rs3829222 T/T Genotype and Low Expression of CALCB Are High-Risk Factors for Adenoid Cystic Carcinoma of Salivary Gland. Disease Markers, 2021.

Gao, F., Liu, G., Wang, J., Huang, S., Ding, F., Lian, W., ... & Liu, Q. (2021). Methylation of CALCA and CALCB in Pancreatic Ductal Adenocarcinoma. Oxidative Medicine and Cellular Longevity, 2021.

Dallmayer, M., Li, J., Ohmura, S., Rubio, R. A., Baldauf, M. C., Hölting, T. L., ... & Grünewald, T. G. (2019). Targeting the CALCB/RAMP1 axis inhibits growth of Ewing sarcoma. Cell death & disease, 10(2), 1-13.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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