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Mouse Anti-CAPZA1 Recombinant Antibody (7C8) (CBMAB-C8602-LY)

This product is antibody recognizes CAPZA1. The antibody 7C8 immunoassay techniques such as: WB.
See all CAPZA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Dog, Monkey, Rat
Clone
7C8
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Full length human recombinant protein of human CAPZA1 (NP_006126) produced in HEK293T cell
Specificity
Human, Dog, Monkey, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1
Introduction
CAPZA1 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1) is a Protein Coding gene. Diseases associated with CAPZA1 include Autosomal Recessive Primary Microcephaly. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding.
An important paralog of this gene is CAPZA2.
Entrez Gene ID
Human829
Dog475857
Rat691149
Monkey705653
UniProt ID
HumanP52907
DogF1P7P3
RatB2GUZ5
MonkeyQ4R959
Alternative Names
Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1; Capping Protein (Actin Filament) Muscle Z-Line, Alpha 1; CapZ Alpha-1; F-Actin-Capping Protein Subunit Alpha-1; CAPPA1; Cap Z; CAPZ; CAZ1;
Function
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Biological Process
Actin cytoskeleton organization Source: GO_Central
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Blood coagulation Source: Reactome
Cell junction assembly Source: UniProtKB
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Innate immune response Source: Reactome
Interleukin-12-mediated signaling pathway Source: Reactome
Protein-containing complex assembly Source: ProtInc
Cellular Location
Cytoskeleton
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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