CAPZA1
CAPZA1 (Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1) is a Protein Coding gene. Diseases associated with CAPZA1 include Autosomal Recessive Primary Microcephaly. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Innate Immune System. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is CAPZA2.
Full Name
Capping Actin Protein Of Muscle Z-Line Alpha Subunit 1
Function
F-actin-capping proteins bind in a Ca2+-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions.
Biological Process
Actin cytoskeleton organization Source: GO_Central
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Blood coagulation Source: Reactome
Cell junction assembly Source: UniProtKB
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Innate immune response Source: Reactome
Interleukin-12-mediated signaling pathway Source: Reactome
Protein-containing complex assembly Source: ProtInc
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Barbed-end actin filament capping Source: GO_Central
Blood coagulation Source: Reactome
Cell junction assembly Source: UniProtKB
Endoplasmic reticulum to Golgi vesicle-mediated transport Source: Reactome
Innate immune response Source: Reactome
Interleukin-12-mediated signaling pathway Source: Reactome
Protein-containing complex assembly Source: ProtInc
Cellular Location
Cytoskeleton
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Anti-CAPZA1 antibodies
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Target: CAPZA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2G4
Application*: F, IH, WB
Target: CAPZA1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 2
Application*: WB, E, IP
Target: CAPZA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2353
Application*: E, WB
Target: CAPZA1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYY-C0941
Application*: WB
Target: CAPZA1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-0805
Application*: F, IF, WB, IH
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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