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Rat Anti-CCL11 Recombinant Antibody (CBYY-C1056) (CBMAB-C2493-YY)

This product is rat antibody that recognizes CCL11. The antibody CBYY-C1056 can be used for immunoassay techniques such as: WB, IHC, Neut
See all CCL11 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C1056
Antibody Isotype
IgG2a
Application
WB, IHC, Neut

Basic Information

Immunogen
E. coli-derived recombinant mouse CCL11/Eotaxin, His24-Pro97, Accession # P48298
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A/G purified
Preservative
PBS
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
chemokine (C-C motif) ligand 11
Entrez Gene ID
6356
UniProt ID
P51671
Alternative Names
C-C Motif Chemokine Ligand 28; Mucosae-Associated Epithelial Chemokine; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 28; Small Inducible Cytokine A28; CC Chemokine CCL28; SCYA28; MEC;
Function
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions (PubMed:8597956).
Binds to CCR3 (PubMed:8631813).
Biological Process
Actin filament organization Source: Ensembl
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Branching involved in mammary gland duct morphogenesis Source: Ensembl
Cell adhesion Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Chronic inflammatory response Source: Ensembl
Cytokine-mediated signaling pathway Source: Reactome
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
ERK1 and ERK2 cascade Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Learning or memory Source: ARUK-UCL
Lymphocyte chemotaxis Source: GO_Central
Mammary duct terminal end bud growth Source: Ensembl
Mast cell chemotaxis Source: Ensembl
Modulation of age-related behavioral decline Source: ARUK-UCL
Monocyte chemotaxis Source: GO_Central
Negative regulation of neurogenesis Source: ARUK-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of angiogenesis Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of endothelial cell proliferation Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: BHF-UCL
Protein phosphorylation Source: ProtInc
Regulation of cell shape Source: UniProtKB
Response to interleukin-13 Source: Ensembl
Response to interleukin-4 Source: Ensembl
Response to radiation Source: ProtInc
Response to virus Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.

Da Ae Kim, S. J. P., Lee, J. Y., Kim, J. H., Lee, S., Lee, E., Jang, I. Y., ... & Kim, B. J. (2021). Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults. Endocrinology and Metabolism, 36(2), 455.

Kurogoushi, R., Hasegawa, T., Akazawa, Y., Iwata, K., Sugimoto, A., Yamaguchi-Ueda, K., ... & Iwamoto, T. (2021). Fibroblast growth factor 2 suppresses the expression of CC motif chemokine 11 through the c-Jun N-terminal kinase pathway in human dental pulp-derived mesenchymal stem cells. Experimental and Therapeutic Medicine, 22(6), 1-8.

Jung, H. W., Park, J. H., & Kim, B. J. (2021). Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults.

Park, S. J., Da Ae Kim, J. Y. L., & Kim, B. J. (2021). In Vitro Effect of CCL11 on Myogenic Differentiation and Its Relevance With Sarcopenia Parameters in Older Adults. Journal of the Endocrine Society, 5(Suppl 1), A234.

Wang, R., & Huang, K. (2020). CCL11 increases the proportion of CD4+ CD25+ Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway. Molecular medicine reports, 21(6), 2522-2532.

Wang, W., Huang, C. Y., Wang, Z. P., Xu, S. S., Qian, T. Y., Chen, Y. D., & Wu, W. G. (2019). Serum CC motif ligand 11/eotaxin-1 may serve as a candidate biomarker for postmenopausal osteoporosis. Journal of medical biochemistry, 38(3), 353.

Kuznik, B. I., Davydov, S. O., Stepanov, A. V., Guseva, E. S., Smolyakov, Y. N., Tsybikov, N. N., & Magen, E. (2018). The role of growth differentiation factors 11 and 15 (GDF11, GDF15), eotaxin 1 (CCL11) and junctional adhesion molecule a (JAMA) in the regulation of blood pressure in women with essential hypertension. MOJ Gerontology & Geriatrics, 3(1), 71-75.

Polacchini, A., Girardi, D., Falco, A., Zanotta, N., Comar, M., De Carlo, N. A., & Tongiorgi, E. (2018). Distinct CCL2, CCL5, CCL11, CCL27, IL-17, IL-6, BDNF serum profiles correlate to different job-stress outcomes. Neurobiology of stress, 8, 82-91.

Kang, W. S., Kim, Y. J., Park, H. J., Kim, S. K., Paik, J. W., & Kim, J. W. (2018). Association of CCL11 promoter polymorphisms with schizophrenia in a Korean population. Gene, 656, 80-85.

Nieh, S. (2017). The role of cancer-associated fibroblast-induced chemokine ligand 11 in tumor microenvironment contributes to the progression of oral cancer.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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