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Rabbit Anti-CCL17 Recombinant Antibody (CBYJT-1061) (CBMAB-T0071-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to CCL17 (C-C Motif Chemokine Ligand 17). The antibody can be used for immunoassay techniques, such as IHC-P, WB.
See all CCL17 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
CBYJT-1061
Antibody Isotype
IgG
Application
IHC-P, WB

Basic Information

Immunogen
A portion of recombinant human TARC protein corresponding to amino acids 24-94
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS
Preservative
0.09% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 24-94

Target

Full Name
chemokine (C-C motif) ligand 17
Introduction
CCL17 is a chemotactic factor for T-lymphocytes but not monocytes or granulocytes. CCL17 may play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. It binds to CCR4.
Entrez Gene ID
Human6361
Mouse20295
UniProt ID
HumanQ92583
MouseQ9WUZ6
Alternative Names
C-C Motif Chemokine Ligand 17; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17; Thymus And Activation-Regulated Chemokine; Chemokine (C-C Motif) Ligand 17; Small-Inducible Cytokine A17; CC Chemokine TARC; SCYA17
Function
Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Multicellular organism development Source: ProtInc
Negative regulation of myoblast differentiation Source: Ensembl
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Cellular Location
Secreted

Tang, N., Zhang, Y. Y., Cheng, J. H., Zhao, Z. B., & Fan, Y. (2021). Cross-talk between CXC chemokine ligand 10-CXC chemokine receptor 3 axis and CC chemokine ligand 17-CC chemokine receptor 4 axis in the pathogenesis of oral lichen planus. Hua xi kou Qiang yi xue za zhi= Huaxi Kouqiang Yixue Zazhi= West China Journal of Stomatology, 39(4), 405-412.

Feng, S., Wang, L., Wang, Y., Wang, Y., Chen, Y., Tian, R., ... & Zhang, S. (2021). Association between serum chemokine CC-motif ligand 17 and prognosis of patients at risk for coronary heart disease.

Dong, Y., Gao, S., Zhang, X., Kou, J., Liu, J., Ye, T., & Shen, H. (2021). CCL17 and CCL22 induce CCR4 receptor expression and promote cytokine-induced killer cells migration. Anti-cancer Drugs.

Chen, Y. T., Hsu, H., Lin, C. C., Pan, S. Y., Liu, S. Y., Wu, C. F., ... & Lin, S. L. (2020). Inflammatory macrophages switch to CCL17‐expressing phenotype and promote peritoneal fibrosis. The Journal of pathology, 250(1), 55-66.

Wilkinson, H. N., Roberts, E. R., Stafford, A. R., Banyard, K. L., Matteucci, P., Mace, K. A., & Hardman, M. J. (2019). Tissue iron promotes wound repair via m2 macrophage polarization and the chemokine (cc motif) ligands 17 and 22. The American journal of pathology, 189(11), 2196-2208.

Li, J., Yang, C., Yang, J., & Zou, L. (2019). Down-regulation of CCL17 in cancer-associated fibroblasts inhibits cell migration and invasion of breast cancer through ERK1/2 pathway. Cancer management and research, 11, 7439.

Lee, M. C., Saleh, R., Achuthan, A., Fleetwood, A. J., Förster, I., Hamilton, J. A., & Cook, A. D. (2018). CCL17 blockade as a therapy for osteoarthritis pain and disease. Arthritis research & therapy, 20(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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