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Mouse Anti-CCL22 Recombinant Antibody (4B5) (CBMAB-C6665-LY)

This product is antibody recognizes CCL22. The antibody 4B5 immunoassay techniques such as: ELISA.
See all CCL22 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
4B5
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
ABCD1 (AAH15541, 1 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MPVLSRPRPW RGNTLKRTAV LLALAAYGAH KVYPLVRQCL APARGLQAPA GEPTQEASGV AAAKAGMNRV FLQRLLWLLR LLFPRVLCRE TGLLALHSAA
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 22
Introduction
CCL22 (C-C Motif Chemokine Ligand 22) is a Protein Coding gene. Diseases associated with CCL22 include Eosinophilic Pneumonia and Dermatitis. Among its related pathways are PEDF Induced Signaling and Cytokine Signaling in Immune system. Gene Ontology (GO) annotations related to this gene include chemokine activity.
Entrez Gene ID
6367
UniProt ID
O00626
Alternative Names
C-C Motif Chemokine Ligand 22; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22; Chemokine (C-C Motif) Ligand 22; Macrophage-Derived Chemokine; CC Chemokine STCP-1; MDC(1-69); SCYA22; MDC; Stimulated T Cell Chemotactic Protein 1;
Function
May play a role in the trafficking of activated/effector T-lymphocytes to inflammatory sites and other aspects of activated T-lymphocyte physiology. Chemotactic for monocytes, dendritic cells and natural killer cells. Mild chemoattractant for primary activated T-lymphocytes and a potent chemoattractant for chronically activated T-lymphocytes but has no chemoattractant activity for neutrophils, eosinophils, and resting T-lymphocytes. Binds to CCR4. Processed forms MDC(3-69), MDC(5-69) and MDC(7-69) seem not be active.
Biological Process
Antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
Cell-cell signaling Source: ProtInc
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytokine-mediated signaling pathway Source: Reactome
G protein-coupled receptor signaling pathway Source: GO_Central
Immune response Source: ProtInc
Inflammatory response Source: GO_Central
Killing of cells of other organism Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Response to virus Source: ProtInc
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
The N-terminal processed forms MDC(3-69), MDC(5-69) and MDC(7-69) are produced by proteolytic cleavage after secretion from monocyte derived dendrocytes.

Xu, H., Lin, S., & Huang, H. (2021). Involvement of increased expression of chemokine C–C motif chemokine 22 (CCL22)/CC chemokine receptor 4 (CCR4) in the inflammatory injury and cartilage degradation of chondrocytes. Cytotechnology, 73(5), 715-726.

Dong, Y., Gao, S., Zhang, X., Kou, J., Liu, J., Ye, T., & Shen, H. (2021). CCL17 and CCL22 induce CCR4 receptor expression and promote cytokine-induced killer cells migration. Anti-cancer Drugs.

Kimura, S., Noguchi, H., Nanbu, U., & Nakayama, T. (2021). Macrophage CCL22 expression promotes lymphangiogenesis in patients with tongue squamous cell carcinoma via IL-4/STAT6 in the tumor microenvironment. Oncology Letters, 21(5), 1-11.

Baer, C., Kimura, S., Iacobucci, I., Feith, D. J., Walter, W., Meggendorfer, M., ... & Haferlach, T. (2020). Recurrent Mutations of the CC Motif Chemokine Ligand 22 (CCL22) Define a Distinct Subgroup of Chronic Lymphoproliferative Disorder of NK Cells (CLPD-NK). Blood, 136, 19.

Ohuchi, K., Fujimura, T., Lyu, C., Amagai, R., Muto, Y., & Aiba, S. (2020). Serum CCL22 levels decreased in parallel with disease activity in CCR4‐positive mycosis fungoides treated with mogamulizumab. Dermatologic Therapy, 33(6), e14099.

Huang, Y. H., Chang, C. Y., Kuo, Y. Z., Fang, W. Y., Kao, H. Y., Tsai, S. T., & Wu, L. W. (2019). Cancer‐associated fibroblast‐derived interleukin‐1β activates protumor C‐C motif chemokine ligand 22 signaling in head and neck cancer. Cancer science, 110(9), 2783-2793.

Kashefi, S., Ahmadi, H., Omranipour, R., Mahmoodzadeh, H., Jafarnezhad-Ansariha, F., Zavareh, F. T., & Mirshafiey, A. (2019). The anti-tumoral effect of β-D-mannuronic acid (M2000) as a novel NSAID on Treg cells frequency and MMP-2, MMP-9, CCL22 and TGFβ1 gene expression in pre-surgical breast cancer patients. Iranian Journal of Allergy, Asthma and Immunology, 80-90.

Li, X., Li, D., Shi, Q., Huang, X., & Ju, X. (2019). Umbilical cord blood‑derived Helios‑positive regulatory T cells promote angiogenesis in acute lymphoblastic leukemia in mice via CCL22 and the VEGFA‑VEGFR2 pathway. Molecular medicine reports, 19(5), 4195-4204.

Wu, S., He, H., Liu, H., Cao, Y., Li, R., Zhang, H., ... & Xu, J. (2018). CC motif chemokine 22 predicts postoperative prognosis and adjuvant chemotherapeutic benefits in patients with stage II/III gastric cancer. Oncoimmunology, 7(6), e1433517.

Wei, Y., Wang, T., Song, H., Tian, L., Lyu, G., Zhao, L., & Xue, Y. (2017). CC motif chemokine 22 ligand (CCL22) concentrations in sera of gastric cancer patients are related to peritoneal metastasis and predict recurrence within one year after radical gastrectomy. Journal of Surgical Research, 211, 266-278.

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For research use only. Not intended for any clinical use.

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