Mouse Anti-CCL5 Recombinant Antibody (2E9/CCL5) (CBMAB-C0881-LY)

Mouse

Mouse

2E9/CCL5

IgG2b, κ

ICFC

Recombinant CCL5

Mouse

IgG2b, κ

Monoclonal

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Liquid

0.09% sodium azide

0.2 mg/ml

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

C-C Motif Chemokine Ligand 5

CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Ulcer Of Lower Limbs and Periapical Granuloma. Among its related pathways are PEDF Induced Signaling and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity.
An important paralog of this gene is CCL3L3.

Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant RANTES protein induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). The processed form RANTES(3-68) acts as a natural chemotaxis inhibitor and is a more potent inhibitor of HIV-1-infection. The second processed form RANTES(4-68) exhibits reduced chemotactic and HIV-suppressive activity compared with RANTES(1-68) and RANTES(3-68) and is generated by an unidentified enzyme associated with monocytes and neutrophils (PubMed:16791620, PubMed:1380064, PubMed:8525373, PubMed:9516414, PubMed:15923218).
May also be an agonist of the G protein-coupled receptor GPR75, stimulating inositol trisphosphate production and calcium mobilization through its activation. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells (PubMed:23979485).

Activation of phospholipase D activity Source: BHF-UCL
Calcium ion transport Source: UniProtKB
Cell-cell signaling Source: BHF-UCL
Cellular calcium ion homeostasis Source: UniProtKB
Cellular response to fibroblast growth factor stimulus Source: UniProtKB
Cellular response to interferon-gamma Source: UniProtKB
Cellular response to interleukin-1 Source: UniProtKB
Cellular response to organic cyclic compound Source: UniProtKB
Cellular response to tumor necrosis factor Source: UniProtKB
Cellular response to virus Source: ARUK-UCL
Chemokine-mediated signaling pathway Source: UniProtKB
Chemotaxis Source: UniProtKB
Cytokine-mediated signaling pathway Source: Reactome
Dendritic cell chemotaxis Source: BHF-UCL
Eosinophil chemotaxis Source: BHF-UCL
Exocytosis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: UniProtKB
Inflammatory response Source: UniProtKB
Leukocyte cell-cell adhesion Source: BHF-UCL
Lipopolysaccharide-mediated signaling pathway Source: UniProtKB
Lymphocyte chemotaxis Source: GO_Central
Macrophage chemotaxis Source: BHF-UCL
MAPK cascade Source: UniProtKB
Monocyte chemotaxis Source: GO_Central
Negative regulation by host of viral transcription Source: UniProtKB
Negative regulation of G protein-coupled receptor signaling pathway Source: UniProtKB
Negative regulation of T cell apoptotic process Source: BHF-UCL
Negative regulation of viral genome replication Source: BHF-UCL
Neutrophil activation Source: BHF-UCL
Neutrophil chemotaxis Source: GO_Central
Positive regulation of activation of Janus kinase activity Source: BHF-UCL
Positive regulation of calcium ion transport Source: UniProtKB
Positive regulation of cell adhesion Source: BHF-UCL
Positive regulation of cell-cell adhesion mediated by integrin Source: BHF-UCL
Positive regulation of cell migration Source: UniProtKB
Positive regulation of cellular biosynthetic process Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of homotypic cell-cell adhesion Source: BHF-UCL
Positive regulation of innate immune response Source: BHF-UCL
Positive regulation of macrophage chemotaxis Source: BHF-UCL
Positive regulation of monocyte chemotaxis Source: BHF-UCL
Positive regulation of natural killer cell chemotaxis Source: UniProtKB
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of phosphorylation Source: BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STAT Source: BHF-UCL
Positive regulation of smooth muscle cell migration Source: BHF-UCL
Positive regulation of smooth muscle cell proliferation Source: BHF-UCL
Positive regulation of T cell apoptotic process Source: BHF-UCL
Positive regulation of T cell chemotaxis Source: BHF-UCL
Positive regulation of T cell migration Source: MGI
Positive regulation of T cell proliferation Source: BHF-UCL
Positive regulation of translational initiation Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: BHF-UCL
Positive regulation of viral genome replication Source: BHF-UCL
Protein kinase B signaling Source: UniProtKB
Regulation of chronic inflammatory response Source: BHF-UCL
Regulation of insulin secretion Source: UniProtKB
Regulation of neuron death Source: UniProtKB
Regulation of T cell activation Source: BHF-UCL
Response to toxic substance Source: UniProtKB
Response to virus Source: BHF-UCL

Secreted

N-terminal processed form RANTES(3-68) is produced by proteolytic cleavage, probably by DPP4, after secretion from peripheral blood leukocytes and cultured sarcoma cells.
The identity of the O-linked saccharides at Ser-27 and Ser-28 are not reported in PubMed:1380064. They are assigned by similarity.