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Mouse Anti-CCL7 Recombinant Antibody (113) (CBMAB-C0205-LY)

This product is antibody recognizes CCL7. The antibody 113 immunoassay techniques such as: ELISA, WB.
See all CCL7 antibodies
Published Data
Fig.1 Expression of Lair-1 in ATL cases.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
113
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Purified Recombinant Human Monocyte Chemotactic Protein-3 (MCP-3)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Ligand 7
Introduction
CCL7 (C-C Motif Chemokine Ligand 7) is a Protein Coding gene. Diseases associated with CCL7 include Diffuse Gastric Cancer and Status Asthmaticus. Among its related pathways are PEDF Induced Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include heparin binding and CCR1 chemokine receptor binding. An important paralog of this gene is CCL2.
Entrez Gene ID
6354
UniProt ID
P80098
Alternative Names
C-C Motif Chemokine Ligand 7; Monocyte Chemoattractant Protein 3; Monocyte Chemotactic Protein 3; Small Inducible Cytokine A7 (Monocyte Chemotactic Protein 3); Chemokine (C-C Motif) Ligand 7; Small-Inducible Cytokine A7; SCYA6; SCYA7;
Function
Chemotactic factor that attracts monocytes and eosinophils, but not neutrophils. Augments monocyte anti-tumor activity. Also induces the release of gelatinase B. This protein can bind heparin. Binds to CCR1, CCR2 and CCR3.
Biological Process
Cell-cell signaling Source: ProtInc
Cellular calcium ion homeostasis Source: ProtInc
Cellular response to ethanol Source: Ensembl
Cellular response to interferon-gamma Source: GO_Central
Cellular response to interleukin-1 Source: GO_Central
Cellular response to tumor necrosis factor Source: GO_Central
Chemokine-mediated signaling pathway Source: GO_Central
Chemotaxis Source: ProtInc
Cytoskeleton organization Source: UniProtKB
Eosinophil chemotaxis Source: UniProtKB
G protein-coupled receptor signaling pathway Source: GO_Central
Inflammatory response Source: GO_Central
Lymphocyte chemotaxis Source: GO_Central
Monocyte chemotaxis Source: GO_Central
Neutrophil chemotaxis Source: GO_Central
Positive regulation of cell migration Source: UniProtKB
Positive regulation of ERK1 and ERK2 cascade Source: GO_Central
Positive regulation of GTPase activity Source: GO_Central
Positive regulation of natural killer cell chemotaxis Source: UniProtKB
Regulation of cell shape Source: UniProtKB
Response to gamma radiation Source: Ensembl
Signal transduction Source: ProtInc
Cellular Location
Secreted
PTM
O-glycosylated.

Waśkiel-Burnat, A., Niemczyk, A., Blicharz, L., Chmielińska, P., Zaremba, M., Gąsecka, A., ... & Rudnicka, L. (2021). Chemokine CC Motif Ligand 7 (CCL7), a Biomarker of Atherosclerosis, Is Associated with the Severity of Alopecia Areata: A Preliminary Study. Journal of Clinical Medicine, 10(22), 5418.

Jeong, M., Wang, Y. Y., Choi, J. Y., Lim, M. C., & Choi, J. H. (2021). CC Chemokine Ligand 7 Derived from Cancer-Stimulated Macrophages Promotes Ovarian Cancer Cell Invasion. Cancers, 13(11), 2745.

Niu, M., Luo, Z., Gong, S., Win, S., Kaplowitz, N., Jiang, Y., & Chen, P. (2020). Intestinal epithelial chemokine (CC motif) ligand 7 overexpression enhances acetaminophen-induced hepatotoxicity in mice. The American journal of pathology, 190(1), 57-67.

Chen, J., Dang, Y., Feng, W., Qiao, C., Liu, D., Zhang, T., ... & Xia, L. (2020). SOX18 promotes gastric cancer metastasis through transactivating MCAM and CCL7. Oncogene, 39(33), 5536-5552.

Kurzejamska, E., Sacharczuk, M., Landázuri, N., Kovtonyuk, O., Lazarczyk, M., Ananthaseshan, S., ... & Religa, P. (2019). Effect of chemokine (CC motif) ligand 7 (CCL7) and its receptor (CCR2) expression on colorectal Cancer behaviors. International journal of molecular sciences, 20(3), 686.

Mariya, S. S., Dewi, F. N., Villiandra, V., Paramastri, Y. A., Iskandriati, D., Saepuloh, U., ... & Sajuthi, D. (2019). Isolation and characterization of CC chemokine ligand 7 (CCL7) in cynomolgus macaques. HAYATI Journal of Biosciences, 26(3), 129-129.

Wu, Z., Tian, Y., Yu, Q., Li, H., Tian, Z., Jiang, H., ... & Yang, X. (2018). The expression and correlation between chemokine CCL7 and ABCE1 in non‑small cell lung cancer. Experimental and therapeutic medicine, 16(4), 3004-3010.

Liu, Y., Cai, Y., Liu, L., Wu, Y., & Xiong, X. (2018). Crucial biological functions of CCL7 in cancer. PeerJ, 6, e4928.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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