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Mouse Anti-CCNA1 Recombinant Antibody (12K76) (CBMAB-C2686-LY)

This product is antibody recognizes CCNA1. The antibody 12K76 immunoassay techniques such as: IHC-F, WB.
See all CCNA1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
12K76
Antibody Isotype
IgG1
Application
IHC-F, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin A1
Introduction
CCNA1 (Cyclin A1) is a Protein Coding gene. Diseases associated with CCNA1 include Myeloid Leukemia and Acute Promyelocytic Leukemia. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding.
An important paralog of this gene is CCNA2.
Entrez Gene ID
8900
UniProt ID
P78396
Alternative Names
Cyclin A1; Testicular Tissue Protein Li 34; Cyclin-A1; CT146;
Function
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells.
Biological Process
Cell division Source: UniProtKB-KW
Male meiosis I Source: ProtInc
Mitotic cell cycle phase transition Source: GO_Central
Protein deubiquitination Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Spermatogenesis Source: ProtInc
Cellular Location
Nucleus
PTM
Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase-promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase.

Bourova-Flin, E., Derakhshan, S., Goudarzi, A., Wang, T., Vitte, A. L., Chuffart, F., ... & Aminishakib, P. (2021). The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma. British Journal of Cancer, 125(8), 1122-1134.

Tsao, C. H., Hsieh, W. C., Yang, R. Y., Lo, Y. H., Tu, T. J., Ke, L. Y., ... & Liu, F. T. (2021). Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2. Glycobiology.

Ge, M., Xu, Q., Kang, T., Li, D., Wang, R., Chen, Z., ... & Liu, H. (2021). Deubiquitinating enzyme inhibitor alleviates cyclin A1‐mediated proteasome inhibitor tolerance in mixed‐lineage leukemia. Cancer science, 112(6), 2287-2298.

Leung, W. K., Workineh, A., Mukhi, S., Tzannou, I., Brenner, D., Watanabe, N., ... & Lulla, P. (2020). Evaluation of cyclin A1–specific T cells as a potential treatment for acute myeloid leukemia. Blood advances, 4(2), 387-397.

Radonova, L., Pauerova, T., Jansova, D., Danadova, J., Skultety, M., Kubelka, M., & Anger, M. (2020). Cyclin A1 in Oocytes Prevents Chromosome Segregation And Anaphase Entry. Scientific reports, 10(1), 1-12.

He, X., Li, S., Shi, W., Lin, Q., Ma, J., Liu, Y., ... & Cao, X. (2019). Cyclin A1 is associated with poor prognosis in oesophageal squamous cell carcinoma. Oncology letters, 18(1), 706-712.

Pandey, S., Moazam, M., Ghimirey, N., Kuerbitz, S. J., & Fraizer, G. C. (2019). WT1 regulates cyclin A1 expression in K562 cells. Oncology reports, 42(5), 2016-2028.

Cao, J., Dong, J., Wang, Y., & Chen, Y. (2019). The expressions of DNA methyltransferase 1 (DNMT1) and cyclin A1 (CCNA1) in cervical carcinogenesis. International journal of clinical and experimental pathology, 12(1), 40.

Panigrahi, S. K., Manterola, M., & Wolgemuth, D. J. (2017). Meiotic failure in cyclin A1-deficient mouse spermatocytes triggers apoptosis through intrinsic and extrinsic signaling pathways and 14-3-3 proteins. PLoS One, 12(3), e0173926.

Lulla, P., Tzannou, I., Brenner, D., Heslop, H. E., Vera, J. F., & Leen, A. M. (2017). Evaluating Cyclin A1 As an Immunotherapeutic Target in Acute Myeloid Leukemia (AML). Blood, 130, 1907.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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