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Mouse Anti-CCND2 Recombinant Antibody (CBYY-C0076) (CBMAB-C0341-YY)

This product is mouse antibody that recognizes CCND2. The antibody CBYY-C0076 can be used for immunoassay techniques such as: FC, IF, WB
See all CCND2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBYY-C0076
Antibody Isotype
IgG2a, IgG2b
Application
FC, IF, WB

Basic Information

Immunogen
Purified histidine-tagged human recombinant full length cyclin D2 protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a, IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein A purified
Buffer
0.2 mg/mL
Preservative
PBS, pH 7.4, 0.2% BSA
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cyclin D2
Entrez Gene ID
Human894
Mouse12444
Rat64033
UniProt ID
HumanP30279
MouseP30280
RatQ04827
Alternative Names
B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200
Function
Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity).
Biological Process
Cell division Source: UniProtKB-KW
Mitotic cell cycle phase transition Source: GO_Central
Negative regulation of apoptotic process Source: BHF-UCL
Positive regulation of cell population proliferation Source: BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
Positive regulation of G1/S transition of mitotic cell cycle Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: GO_Central
Cellular Location
Cytoplasm; Nucleus; Membrane. Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated into the nucleus through interaction with KIP/CIP family members.
Isoform 2: Cytoplasm
Involvement in disease
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3): A syndrome characterized by megalencephaly, ventriculomegaly that may lead to hydrocephalus, and polymicrogyria; polydactyly may also be seen. There is considerable phenotypic similarity between this disorder and the megalencephaly-capillary malformation syndrome.
PTM
Polyubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.

Qian, Y., Wang, H., Zhang, Y., Wang, J. W., Fan, Y. C., Gao, S., & Wang, K. (2021). Hypermethylation of Cyclin D2 Predicts Poor Prognosis of Hepatitis B Virus-Associated Hepatocellular Carcinoma after Hepatectomy. The Tohoku Journal of Experimental Medicine, 254(3), 233-243.

Zhu, S., Zhang, J., Cui, Y., Tang, X., Gao, X., Li, D., & Jia, W. (2020). Long non-coding RNA HOXA11-AS upregulates Cyclin D2 to inhibit apoptosis and promote cell cycle progression in nephroblastoma by recruiting forkhead box P2. American journal of cancer research, 10(1), 284.

Qian, Y., Wang, J. W., Yu-Fang, X. D. Y., Fan, Y. C., Gao, S., & Wang, K. (2020). Measurement of Cyclin D2 (CCND2) Gene Promoter Methylation in Plasma and Peripheral Blood Mononuclear Cells and Alpha-Fetoprotein Levels in Patients with Hepatitis B Virus-Associated Hepatocellular Carcinoma. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research, 26, e927444-1.

Pandya, P., Jethva, M., Rubin, E., Birnbaum, R. Y., Braiman, A., & Isakov, N. (2019). PICOT binding to chromatin-associated EED negatively regulates cyclin D2 expression by increasing H3K27me3 at the CCND2 gene promoter. Cell death & disease, 10(10), 1-15.

Ding, Z. Y., Li, R., Zhang, Q. J., Wang, Y., Jiang, Y., Meng, Q. Y., ... & Wu, G. H. (2019). Prognostic role of cyclin D2/D3 in multiple human malignant neoplasms: A systematic review and meta‐analysis. Cancer medicine, 8(6), 2717-2729.

Huang, R., Hu, Z., Cao, Y., Li, H., Zhang, H., Su, W., ... & Jiang, L. (2019). MiR-652-3p inhibition enhances endothelial repair and reduces atherosclerosis by promoting Cyclin D2 expression. EBioMedicine, 40, 685-694.

Cameron, S. R., Nandi, S., Kahn, T. G., Barrasa, J. I., Stenberg, P., & Schwartz, Y. B. (2018). PTE, a novel module to target Polycomb Repressive Complex 1 to the human cyclin D2 (CCND2) oncogene. Journal of Biological Chemistry, 293(37), 14342-14358.

Koochakpoor, G., Mirmiran, P., Daneshpour, M. S., Hosseini-Esfahani, F., Sedaghati-Khayat, B., Hosseini, S. A., & Azizi, F. (2018). Dietary factors influence the association of cyclin D2 polymorphism rs11063069 with the risk of metabolic syndrome. Nutrition Research, 52, 48-56.

Zhao, Z., Yang, F., Liu, Y., Fu, K., & Jing, S. (2018). MicroRNA‑409‑3p suppresses cell proliferation and cell cycle progression by targeting cyclin D2 in papillary thyroid carcinoma. Oncology letters, 16(4), 5237-5242.

Wang, Y., Xue, J., Kuang, H., Zhou, X., Liao, L., & Yin, F. (2017). microRNA-1297 inhibits the growth and metastasis of colorectal cancer by suppressing cyclin D2 expression. DNA and cell biology, 36(11), 991-999.

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For research use only. Not intended for any clinical use.

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