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Mouse Anti-CCP110 Recombinant Antibody (1A3C12) (CBMAB-AP1654LY)


See all CCP110 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A3C12
Antibody Isotype
IgG2a
Application
ELISA, WB

Basic Information

Immunogen
Fusion Protein of CP110
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Centriolar Coiled-Coil Protein 110
Introduction
CCP110 (Centriolar Coiled-Coil Protein 110) is a Protein Coding gene. Diseases associated with CCP110 include Spinocerebellar Ataxia 11 and Townes-Brocks Syndrome. Among its related pathways are Organelle biogenesis and maintenance and Metabolism of proteins.
Entrez Gene ID
9738
UniProt ID
O43303
Alternative Names
Centriolar Coiled-Coil Protein 110; Centrosomal Protein Of 110 KDa; Cep110; CP110; Centriolar Coiled-Coil Protein Of 110 KDa; Centriolar Coiled Coil Protein 110kDa; Centriolar Coiled-Coil Protein 110kDa; Centrosomal Protein CP110; KIAA0419;
Function
Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:17719545 PubMed:17681131, PubMed:23486064).
Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity).
Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed:16760425).
Biological Process
Centriole replication Source: UniProtKB
Centrosome duplication Source: UniProtKB
Ciliary basal body organization Source: UniProtKB
Ciliary basal body-plasma membrane docking Source: Reactome
G2/M transition of mitotic cell cycle Source: Reactome
Negative regulation of centriole elongation Source: GO_Central
Negative regulation of cilium assembly Source: UniProtKB
Positive regulation of cilium assembly Source: UniProtKB
Protein deubiquitination Source: Reactome
Regulation of cytokinesis Source: UniProtKB
Regulation of G2/M transition of mitotic cell cycle Source: Reactome
Cellular Location
Centriole; Centrosome; Cilium basal body. Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis and localizes only to the daughter centriole in ciliated cells. In cytotoxic T lymphocytes remains associated with the mother centriole during docking of the centrosome at the immunological synapse upon target contact.
PTM
Phosphorylated by CDKs.
Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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