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Recombinant Rabbit Anti-CCR7 Antibody (CBAb054) (CBMAB-Ab054-LY)

The product is antibody recognizes CCR7. The antibody CBAb054 immunoassay techniques such as: WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200; IP 1:20-1:50.
See all CCR7 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBAb054
Antibody Isotype
IgG
Application
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200; IP 1:20-1:50

Basic Information

Immunogen
Recombinant protein of human CCR7
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-C Motif Chemokine Receptor 7
Introduction
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
Human1236
Mouse12775
Rat287673
UniProt ID
HumanP32248
MouseP47774
RatQ6U2D6
Alternative Names
CCR7; BLR2; CC-CKR-7; CCR-7; CD197; CDw197; CMKBR7; EBI1; C-C chemokine receptor type 7
Function
Receptor for the MIP-3-beta chemokine. Probable mediator of EBV effects on B-lymphocytes or of normal lymphocyte functions.
Biological Process
Activation of GTPase activity Source: BHF-UCL
Calcium-mediated signaling Source: GO_Central
Cell chemotaxis Source: GO_Central
Cellular response to cytokine stimulus Source: BHF-UCL
Dendritic cell chemotaxis Source: BHF-UCL
Establishment of T cell polarity Source: BHF-UCL
G protein-coupled receptor signaling pathway Source: BHF-UCL
Homeostasis of number of cells Source: Ensembl
Immune response Source: GO_Central
Inflammatory response Source: BHF-UCL
Lymphocyte migration into lymph node Source: BHF-UCL
Mature conventional dendritic cell differentiation Source: BHF-UCL
Myeloid dendritic cell chemotaxis Source: BHF-UCL
Negative regulation of dendritic cell apoptotic process Source: BHF-UCL
Negative regulation of interleukin-12 production Source: BHF-UCL
Negative thymic T cell selection Source: Ensembl
Positive regulation of actin filament polymerization Source: BHF-UCL
Positive regulation of cell adhesion Source: BHF-UCL
Positive regulation of cell-matrix adhesion Source: BHF-UCL
Positive regulation of cell motility Source: BHF-UCL
Positive regulation of cytosolic calcium ion concentration Source: GO_Central
Positive regulation of dendritic cell antigen processing and presentation Source: BHF-UCL
Positive regulation of dendritic cell chemotaxis Source: BHF-UCL
Positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Positive regulation of filopodium assembly Source: BHF-UCL
Positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation Source: BHF-UCL
Positive regulation of humoral immune response Source: BHF-UCL
Positive regulation of hypersensitivity Source: BHF-UCL
Positive regulation of I-kappaB kinase/NF-kappaB signaling Source: BHF-UCL
Positive regulation of immunological synapse formation Source: BHF-UCL
Positive regulation of interleukin-12 production Source: BHF-UCL
Positive regulation of JNK cascade Source: BHF-UCL
Positive regulation of neutrophil chemotaxis Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase activity Source: BHF-UCL
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of pseudopodium assembly Source: BHF-UCL
Positive regulation of T cell costimulation Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: Ensembl
Regulation of dendritic cell dendrite assembly Source: BHF-UCL
Regulation of interferon-gamma production Source: BHF-UCL
Regulation of interleukin-1 beta production Source: BHF-UCL
Release of sequestered calcium ion into cytosol Source: BHF-UCL
Response to lipopolysaccharide Source: Ensembl
Response to nitric oxide Source: BHF-UCL
Response to prostaglandin E Source: BHF-UCL
Ruffle organization Source: BHF-UCL
Cellular Location
Cell membrane
Topology
Extracellular: 25-59
Helical: 60-86
Cytoplasmic: 87-95
Helical: 96-116
Extracellular: 117-130
Helical: 131-152
Cytoplasmic: 153-170
Helical: 171-191
Extracellular: 192-219
Helical: 220-247
Cytoplasmic: 248-263
Helical: 264-289
Extracellular: 290-313
Helical: 314-331
Cytoplasmic: 332-378

Nagasawa, S., Tsuchida, K., Shiozawa, M., Hiroshima, Y., Kimura, Y., Hashimoto, I., ... & Oshima, T. (2021). Clinical Significance of Chemokine Receptor CXCR4 and CCR7 mRNA Expression in Patients With Colorectal Cancer. Anticancer Research, 41(9), 4489-4495.

Wen, Y., Rudemiller, N. P., Zhang, J., Lu, X., Ren, J., Privratsky, J. R., ... & Crowley, S. D. (2020). CC Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking. Hypertension, 75(3), 869-876.

Yan, Y., Chen, R., Wang, X., Hu, K., Huang, L., Lu, M., & Hu, Q. (2019). CCL19 and CCR7 expression, signaling pathways, and adjuvant functions in viral infection and prevention. Frontiers in cell and developmental biology, 7, 212.

An, S., Tiruthani, K., Wang, Y., Xu, L., Hu, M., Li, J., ... & Huang, L. (2019). Locally Trapping the C‐C Chemokine Receptor Type 7 by Gene Delivery Nanoparticle Inhibits Lymphatic Metastasis Prior to Tumor Resection. Small, 15(9), 1805182.

Jaeger, K., Bruenle, S., Weinert, T., Guba, W., Muehle, J., Miyazaki, T., ... & Standfuss, J. (2019). Structural basis for allosteric ligand recognition in the human CC chemokine receptor 7. Cell, 178(5), 1222-1230.

Mueller, P. A., Zhu, L., Tavori, H., Huynh, K., Giunzioni, I., Stafford, J. M., ... & Fazio, S. (2018). Deletion of macrophage low-density lipoprotein receptor-related protein 1 (LRP1) accelerates atherosclerosis regression and increases CC chemokine receptor type 7 (CCR7) expression in plaque macrophages. Circulation, 138(17), 1850-1863.

Zhang, J. F., Li, Y., Zhang, A. Z., He, Q. Q., Du, Y. C., & Cao, W. (2018). Expression and pathological significance of CC chemokine receptor 7 and its ligands in the airway of asthmatic rats exposed to cigarette smoke. Journal of thoracic disease, 10(9), 5459.

Wu, J., Li, L., Liu, J., Wang, Y., Wang, Z., Wang, Y., ... & Yang, R. (2018). CC chemokine receptor 7 promotes triple-negative breast cancer growth and metastasis. Acta biochimica et biophysica Sinica, 50(9), 835-842.

Zhong, G., Chen, L., Yin, R., Qu, Y., Bao, Y., Xiao, Q., ... & Tian, H. (2017). Chemokine (C‑C motif) ligand 21/C‑C chemokine receptor type 7 triggers migration and invasion of human lung cancer cells by epithelial‑mesenchymal transition via the extracellular signal‑regulated kinase signaling pathway. Molecular medicine reports, 15(6), 4100-4108.

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For research use only. Not intended for any clinical use.

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