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Rat Anti-CD226 Recombinant Antibody (CBYY-C0248) (CBMAB-C0721-YY)

This product is rat antibody that recognizes CD226. The antibody CBYY-C0248 can be used for immunoassay techniques such as: FC
See all CD226 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBYY-C0248
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Jurkat cells transfected with mouse CD226
Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
0.2 mg/mL
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD226 Molecule
Entrez Gene ID
10666
UniProt ID
Q15762
Alternative Names
Carbonyl Reductase 3; Short Chain Dehydrogenase/Reductase Family 21C Member 2; NADPH-Dependent Carbonyl Reductase 3; EC 1.1.1.184; Short Chain Dehydrogenase/Reductase Family 21C, Member 2; Epididymis Secretory Protein Li 25; Carbonyl Reductase (NADPH) 3;
Function
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704).
Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
Biological Process
Cell adhesion Source: ProtInc
Cell recognition Source: BHF-UCL
Positive regulation of Fc receptor mediated stimulatory signaling pathway Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of interferon-gamma production Source: GO_Central
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell cytokine production Source: GO_Central
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of immune response Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 19-254
Helical: 255-275
Cytoplasmic: 276-336

Bi, J. (2021). CD226: a potent driver of antitumor immunity that needs to be maintained. Cellular & Molecular Immunology, 1-2.

Feng, M., Wu, Z., Zhou, Y., Wei, Z., Tian, E., Mei, S., ... & Zhu, D. (2021). BCL9 regulates CD226 and CD96 checkpoints in CD8+ T cells to improve PD-1 response in cancer. Signal transduction and targeted therapy, 6(1), 1-14.

Huang, Z., Qi, G., Miller, J. S., & Zheng, S. G. (2020). CD226: An emerging role in immunologic diseases. Frontiers in cell and developmental biology, 8, 564.

Wang, N., Yi, H., Fang, L., Jin, J., Ma, Q., Shen, Y., ... & Chen, L. (2020). CD226 attenuates Treg proliferation via Akt and Erk signaling in an EAE model. Frontiers in immunology, 11, 1883.

Shapiro, M. R., Yeh, W. I., Longfield, J. R., Gallagher, J., Infante, C. M., Wellford, S., ... & Brusko, T. M. (2020). CD226 deletion reduces Type 1 diabetes in the NOD mouse by impairing thymocyte development and peripheral T cell activation. Frontiers in immunology, 11, 2180.

Weulersse, M., Asrir, A., Pichler, A. C., Lemaitre, L., Braun, M., Carrié, N., ... & Martinet, L. (2020). Eomes-dependent loss of the co-activating receptor CD226 restrains CD8+ T cell anti-tumor functions and limits the efficacy of cancer immunotherapy. Immunity, 53(4), 824-839.

Wang, H., Qi, J., Zhang, S., Li, Y., Tan, S., & Gao, G. F. (2019). Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5. Proceedings of the National Academy of Sciences, 116(3), 988-996.

Wang, N., Liang, S., Jin, J., Fang, L., Ma, Q., Wang, X., ... & Chen, L. (2019). CD226 attenuates Treg suppressive capacity via CTLA-4 and TIGIT during EAE. Immunologic research, 67(6), 486-496.

Fourcade, J., Sun, Z., Chauvin, J. M., Ka, M., Davar, D., Pagliano, O., ... & Zarour, H. M. (2018). CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI insight, 3(14).

Wagner, A. K., Kadri, N., Snäll, J., Brodin, P., Gilfillan, S., Colonna, M., ... & Chambers, B. J. (2017). Expression of CD226 is associated to but not required for NK cell education. Nature communications, 8(1), 1-14.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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