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CD226

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include Ovarian Cystic Teratoma and Mature Teratoma Of The Ovary. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cell adhesion molecule binding.

Full Name

CD226 Molecule

Function

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704).
Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).

Biological Process

Cell adhesion Source: ProtInc
Cell recognition Source: BHF-UCL
Positive regulation of Fc receptor mediated stimulatory signaling pathway Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of interferon-gamma production Source: GO_Central
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell cytokine production Source: GO_Central
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of immune response Source: Reactome
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 19-254
Helical: 255-275
Cytoplasmic: 276-336

Anti-CD226 antibodies

Rabbit Anti-CD226 Polyclonal Antibody (PTM-CBPAB-0443YC) (PTM-CBPAB-0443YC)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Application*: E, IF, IH, WB

Rabbit Anti-CD226 (Phosphorylated S329) Polyclonal Antibody (PTM-CBPAB-0444YC) (PTM-CBPAB-0444YC)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Application*: E, IF, P, WB

Rat Anti-CD226 Recombinant Antibody (TX42.1) (CBMAB-C10113-LY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2a, κ

Specificity: Mouse

Clone: TX42.1

Application*: F

Mouse Anti-CD226 Recombinant Antibody (MM0248-1X20) (CBMAB-C10114-LY)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: MM0248-1X20

Application*: WB, N

Rabbit Anti-CD226 Recombinant Antibody (EG535) (CBMAB-EN623-LY)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: EG535

Application*: WB: 1:500~1:1000 IHC: 1:50~1:100 IF: 1:100~1:500 ELISA: 1:40000

Mouse Anti-CD226 Recombinant Antibody (102511) (CBMAB-D0064-YC)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 102511

Application*: WB, F, N

Mouse Anti-CD226 Recombinant Antibody (14L368) (CBMAB-D0065-YC)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 14L368

Application*: N, WB

Mouse Anti-CD226 Recombinant Antibody (1X20) (CBMAB-D0066-YC)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1X20

Application*: WB, P, B, N

Mouse Anti-CD226 Recombinant Antibody (CBYCD-128) (CBMAB-D0068-YC)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYCD-128

Application*: WB, IC, P, C, E

Rat Anti-CD226 Recombinant Antibody (TX25) (CBMAB-D0069-YC)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2a

Specificity: Human

Clone: TX25

Application*: F

Rabbit Anti-CD226 Recombinant Antibody (CBYCD-529) (CBMAB-D0070-YC)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBYCD-529

Application*: E, WB

Rat Anti-CD226 Recombinant Antibody (TX92) (CBMAB-D0073-YC)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: TX92

Application*: F, FN

Rat Anti-CD226 Recombinant Antibody (10E5) (CBMAB-C0183-LY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: 10E5

Application*: F

Rat Anti-CD226 Recombinant Antibody (CBYY-C0248) (CBMAB-C0721-YY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2a

Specificity: Mouse

Clone: CBYY-C0248

Application*: F

Mouse Anti-CD226 Recombinant Antibody (CBYY-C1272) (CBMAB-C2710-YY)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYY-C1272

Application*: F, IP

Recombinant Rat Anti-CD226 Antibody (CBHb108) (CBMAB-Hb436-LY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBHb108

Application*: FC, FuncS

Rabbit Anti-CD226 Recombinant Antibody (CBR063G) (CBMAB-BT012LY)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBR063G

Application*: WB, IP, IHC, ICC

Rabbit Anti-CD226 Recombinant Antibody (CBFYC-0118) (CBMAB-C0135-FY)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-0118

Application*: F

Rat Anti-CD226 Recombinant Antibody (CBFYC-0315) (CBMAB-C0350-FY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgM, κ

Specificity: Mouse

Clone: CBFYC-0315

Application*: F

Rabbit Anti-CD226 (AA 1-254) Recombinant Antibody (CBFYC-0484) (CBMAB-C0533-FY)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse

Clone: CBFYC-0484

Application*: E

Mouse Anti-CD226 Recombinant Antibody (CBFYC-1169) (CBMAB-C1227-FY)

SDS

Target: CD226

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1169

Application*: F, N, WB

Rat Anti-CD226 Recombinant Antibody (CBFYC-1170) (CBMAB-C1228-FY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: CBFYC-1170

Application*: F

Rabbit Anti-CD226 Recombinant Antibody (CBFYC-1171) (CBMAB-C1229-FY)

SDS

Target: CD226

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBFYC-1171

Application*: E

Rat Anti-CD226 Recombinant Antibody (CBFYC-1172) (CBMAB-C1230-FY)

SDS

Target: CD226

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBFYC-1172

Application*: F, FN

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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