CD226

CD226 (CD226 Molecule) is a Protein Coding gene. Diseases associated with CD226 include Ovarian Cystic Teratoma and Mature Teratoma Of The Ovary. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include protein kinase binding and cell adhesion molecule binding.
Full Name
CD226 Molecule
Alternative Names
CD226 Molecule; CD226 Antigen; DNAM-1; DNAM1; T Lineage-Specific Activation Antigen 1 Antigen; Platelet And T Cell Activation Antigen 1;
Function
Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell (PubMed:8673704).
Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding (PubMed:26755705).
Biological Process
Cell adhesion Source: ProtInc
Cell recognition Source: BHF-UCL
Positive regulation of Fc receptor mediated stimulatory signaling pathway Source: BHF-UCL
Positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
Positive regulation of interferon-gamma production Source: GO_Central
Positive regulation of mast cell activation Source: BHF-UCL
Positive regulation of natural killer cell cytokine production Source: GO_Central
Positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
Positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
Positive regulation of T cell receptor signaling pathway Source: UniProtKB
Regulation of immune response Source: Reactome
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Topology
Extracellular: 19-254
Helical: 255-275
Cytoplasmic: 276-336
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Anti-CD226 antibodies

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Rat Anti-CD226 Recombinant Antibody (AG14) (V2LY-0524-LY90)

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Target: CD226
Host: Rat
Antibody Isotype: IgG2a, κ
Specificity: Mouse
Clone: AG14
Application*: F, In Vivo
In Vivo Assay
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (DX11) (CBMAB-D0064-YC)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: DX11
Application*: IF, F, IH
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (CBT2872) (V2LY-0625-LY866)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT2872
Application*: WB
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (CBT3094) (V2LY-0625-LY1749)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3094
Application*: IH, F
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (CBT4116) (V2LY-0625-LY1748)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4116
Application*: IH, F
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (CBYY-C1272) (CBMAB-C2710-YY)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-C1272
Application*: E
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (CBFYC-1169) (CBMAB-C1227-FY)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-1169
Application*: F, IP, WB
Datasheet SDS

Rabbit Anti-CD226 Recombinant Antibody (CBFYC-0484) (CBMAB-C0533-FY)

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Target: CD226
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYC-0484
Application*: E
Datasheet SDS

Rabbit Anti-CD226 Recombinant Antibody (CBFYC-0118) (CBMAB-C0135-FY)

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Target: CD226
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse
Clone: CBFYC-0118
Application*: F, E
Datasheet SDS

Rat Anti-CD226 Recombinant Antibody (10E5) (CBMAB-C0183-LY)

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Target: CD226
Host: Rat
Antibody Isotype: IgG2b
Specificity: Mouse
Clone: 10E5
Application*: F
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (CBYCD-128) (CBMAB-D0068-YC)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBYCD-128
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (1X20) (CBMAB-D0066-YC)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1X20
Application*: WB, N
Functional Assay
Datasheet SDS

Mouse Anti-CD226 Recombinant Antibody (D0065) (CBMAB-D0065-YC)

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Target: CD226
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: D0065
Application*: N, WB, F
Functional Assay
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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