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Mouse Anti-CD44 v10 Recombinant Antibody (VFF-14) (CBMAB-0204CQ)

This product is a mouse antibody that recognizes CD44 v10. The antibody VFF-14 can be used for immunoassay techniques such as: WB, FC.
See all CD44 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
VFF-14
Antibody Isotype
IgG1
Application
WB, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Introduction
CD44 is an integral cell membrane glycoprotein with a postulated role in matrix adhesion lymphocyte activation and lymph node homing. Screaton et al. (1992) found that the CD44 gene contains 19 exons spanning 50 kb of genomic DNA. They identified 10 alternatively spliced exons within the extracellular domain, including 1 exon that had not previously been reported. This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
Entrez Gene ID
960
UniProt ID
P16070
Alternative Names
CD44 Molecule (Indian Blood Group); Hematopoietic Cell E- And L-Selectin Ligand; GP90 Lymphocyte Homing/Adhesion Receptor; Chondroitin Sulfate Proteoglycan 8; Extracellular Matrix Receptor III; Heparan Sulfate Proteoglycan; Phagocytic Glycoprotein 1; Hyaluronate Receptor; Hermes Antigen; ECMR-III; HUTCH-I; Epican; CDW44; MDU2; MDU3; MIC4; LHR; CD44 Antigen (Homing Function And Indian Blood Group System);Homing Function And Indian Blood Group System; Cell Surface Glycoprotein CD44; Phagocytic Glycoprotein I; Soluble CD44; CD44 Antigen; CSPG8; HCELL; PGP-1; PGP-I; MC56; Pgp1; IN

Liang, Y., Wang, Y., Wang, L., Liang, Z., Li, D., Xu, X., ... & Niu, H. (2021). Self-crosslinkable chitosan-hyaluronic acid dialdehyde nanoparticles for CD44-targeted siRNA delivery to treat bladder cancer. Bioactive materials, 6(2), 433-446.

Al-Othman, N., Alhendi, A., Ihbaisha, M., Barahmeh, M., Alqaraleh, M., & Al-Momany, B. Z. (2020). Role of CD44 in breast cancer. Breast disease, 39(1), 1-13.

Godavarthy, P. S., Kumar, R., Herkt, S. C., Pereira, R. S., Hayduk, N., Weissenberger, E. S., ... & Krause, D. S. (2020). The vascular bone marrow niche influences outcome in chronic myeloid leukemia via the E-selectin-SCL/TAL1-CD44 axis. Haematologica, 105(1), 136.

Zhang, R., Rejeeth, C., Xu, W., Zhu, C., Liu, X., Wan, J., ... & Qian, K. (2019). Label-free electrochemical sensor for cd44 by ligand-protein interaction. Analytical chemistry, 91(11), 7078-7085.

Skandalis, S. S., Karalis, T. T., Chatzopoulos, A., & Karamanos, N. K. (2019). Hyaluronan-CD44 axis orchestrates cancer stem cell functions. Cellular signalling, 63, 109377.

Chen, C., Zhao, S., Karnad, A., & Freeman, J. W. (2018). The biology and role of CD44 in cancer progression: therapeutic implications. Journal of hematology & oncology, 11(1), 1-23.

Morath, I., Jung, C., Lévêque, R., Linfeng, C., Toillon, R. A., Warth, A., & Orian-Rousseau, V. (2018). Differential recruitment of CD44 isoforms by ErbB ligands reveals an involvement of CD44 in breast cancer. Oncogene, 37(11), 1472-1484.

Klement, J. D., Paschall, A. V., Redd, P. S., Ibrahim, M. L., Lu, C., Yang, D., ... & Liu, K. (2018). An osteopontin/CD44 immune checkpoint controls CD8+ T cell activation and tumor immune evasion. The Journal of clinical investigation, 128(12), 5549-5560.

Suleiman, M., Abdulrahman, N., Yalcin, H., & Mraiche, F. (2018). The role of CD44, hyaluronan and NHE1 in cardiac remodeling. Life sciences, 209, 197-201.

Cortes-Dericks, L., & Schmid, R. A. (2017). CD44 and its ligand hyaluronan as potential biomarkers in malignant pleural mesothelioma: evidence and perspectives. Respiratory research, 18(1), 1-12.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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