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Mouse Anti-CD48 Recombinant Antibody (CBYY-C1477) (CBMAB-C2915-YY)

This product is mouse antibody that recognizes CD48. The antibody CBYY-C1477 can be used for immunoassay techniques such as: ELISA, ICC, WB
See all CD48 antibodies

Summary

Host Animal
Mouse
Specificity
Goat, Human
Clone
CBYY-C1477
Antibody Isotype
IgG2b
Application
ELISA, ICC, WB

Basic Information

Immunogen
Recombinant corresponding to aa27-220 of human CD48 expressed in NS0
Specificity
Goat, Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Protein G purified
Buffer
0.5 mg/mL
Preservative
PBS, 5% trehalose
Concentration
Lyophilized
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD48 Molecule
Entrez Gene ID
Human4179
Goat108635603
UniProt ID
HumanP15529
Alternative Names
CD55 Molecule (Cromer Blood Group); CD55 Molecule, Decay Accelerating Factor For Complement (Cromer Blood Group); CD55 Antigen; DAF; CR; Decay Accelerating Factor For Complement (CD55, Cromer Blood Group System);
Function
Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.
Biological Process
Defense response Source: ProtInc
Leukocyte migration Source: Reactome
Regulation of adaptive immune response Source: InterPro
Cellular Location
Cell membrane

Wang, Z., He, L., Li, W., Xu, C., Zhang, J., Wang, D., ... & Li, M. (2021). GDF15 induces immunosuppression via CD48 on regulatory T cells in hepatocellular carcinoma. Journal for immunotherapy of cancer, 9(9).

Ziblat, A., Iraolagoitia, X. L. R., Nuñez, S. Y., Torres, N. I., Secchiari, F., Sierra, J. M., ... & Zwirner, N. W. (2021). Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1. Frontiers in immunology, 12, 2143.

Wang, Z., Xie, C., Li, Y., Cai, J., Tang, J., Jian, J., ... & Lu, Y. (2020). Molecular characterization and expression of CD48 in Nile tilapia (Oreochromis niloticus) in response to different stimulus. Fish & shellfish immunology, 97, 515-522.

Martínez-Vicente, P., Farré, D., Engel, P., & Angulo, A. (2020). Divergent Traits and Ligand-Binding Properties of the Cytomegalovirus CD48 Gene Family. Viruses, 12(8), 813.

Wang, Z., Xiao, Y., Guan, W., Wang, M., Chen, J., Zhang, L., ... & Yu, L. (2020). Acute myeloid leukemia immune escape by epigenetic CD48 silencing. Clinical Science, 134(2), 261-271.

Zou, C., Zhu, C., Guan, G., Guo, Q., Liu, T., Shen, S., ... & Cheng, W. (2019). CD48 is a key molecule of immunomodulation affecting prognosis in glioma. OncoTargets and therapy, 12, 4181.

Pahima, H., Puzzovio, P. G., & Levi-Schaffer, F. (2019). 2B4 and CD48: A powerful couple of the immune system. Clinical Immunology, 204, 64-68.

Martinez-Vicente, P., Farré, D., Sánchez, C., Alcamí, A., Engel, P., & Angulo, A. (2019). Subversion of natural killer cell responses by a cytomegalovirus-encoded soluble CD48 decoy receptor. PLoS pathogens, 15(4), e1007658.

Huang, C. H., Liao, Y. J., Chiou, T. J., Huang, H. T., Lin, Y. H., & Twu, Y. C. (2019). TGF-β regulated leukemia cell susceptibility against NK targeting through the down-regulation of the CD48 expression. Immunobiology, 224(5), 649-658.

Liu, R., Wu, C., Li, L., Chi, F., Zhang, T., Xu, Y., ... & Wang, L. (2019). CD48 and α7 nicotinic acetylcholine receptor synergistically regulate fimH-mediated Escherichia coli K1 penetration and neutrophil transmigration across human brain microvascular endothelial cells. The Journal of infectious diseases, 219(3), 470-479.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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