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Mouse Anti-CD93 (AA 474-535) Recombinant Antibody (1A10E10) (CBMAB-C1554-FY)

This product is mouse antibody that recognizes CD93. The antibody 1A10E10 can be used for immunoassay techniques such as: WB, FC, ELISA, IHC, IF, IHC-P.
See all CD93 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A10E10
Antibody Isotype
IgG1
Application
WB, FC, ELISA, IHC, IF, IHC-P

Basic Information

Immunogen
Purified recombinant fragment of human CD93 (AA: 474-535) expressed in E. Coli
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 474-535

Target

Full Name
CD93 molecule
Introduction
CD93 (CD93 Molecule) is a Protein Coding gene. Among its related pathways are Innate Immune System and Immune response Lectin induced complement pathway. Gene Ontology (GO) annotations related to this gene include calcium ion binding and carbohydrate binding. An important paralog of this gene is THBD.
Entrez Gene ID
22918
UniProt ID
Q9NPY3
Alternative Names
CD93 Molecule; CD93 Antigen; Complement Component 1 Q Subcomponent Receptor 1; Matrix-Remodeling-Associated Protein 4; Matrix-Remodelling Associated 4; C1q/MBL/SPA Receptor; C1qR(P); C1qRP; C1QR1
Function
Receptor (or element of a larger receptor complex) for C1q, mannose-binding lectin (MBL2) and pulmonary surfactant protein A (SPA). May mediate the enhancement of phagocytosis in monocytes and macrophages upon interaction with soluble defense collagens. May play a role in intercellular adhesion.
Biological Process
Cell-cell adhesion Source: UniProtKB
Macrophage activation Source: UniProtKB
Neutrophil degranulation Source: Reactome
Phagocytosis Source: UniProtKB
Viral process Source: UniProtKB-KW
Cellular Location
Membrane
Topology
Extracellular: 24-580
Helical: 581-601
Cytoplasmic: 602-652
PTM
N- and O-glycosylated.

Sun, Y., Chen, W., Torphy, R. J., Yao, S., Zhu, G., Lin, R., ... & Zhu, Y. (2021). Blockade of the CD93 pathway normalizes tumor vasculature to facilitate drug delivery and immunotherapy. Science translational medicine, 13(604), eabc8922.

Barbera, S., Raucci, L., Lugano, R., Tosi, G. M., Dimberg, A., Santucci, A., ... & Orlandini, M. (2021). CD93 Signaling via Rho Proteins Drives Cytoskeletal Remodeling in Spreading Endothelial Cells. International Journal of Molecular Sciences, 22(22), 12417.

Barbera, S., Lugano, R., Pedalina, A., Mongiat, M., Santucci, A., Tosi, G. M., ... & Orlandini, M. (2021). The C-type lectin CD93 controls endothelial cell migration via activation of the Rho family of small GTPases. Matrix Biology.

Kinstrie, R., Horne, G. A., Morrison, H., Irvine, D., Munje, C., Castañeda, E. G., ... & Copland, M. (2020). CD93 is expressed on chronic myeloid leukemia stem cells and identifies a quiescent population which persists after tyrosine kinase inhibitor therapy. Leukemia, 34(6), 1613-1625.

Tosi, G. M., Neri, G., Barbera, S., Mundo, L., Parolini, B., Lazzi, S., ... & Orlandini, M. (2020). The Binding of CD93 to Multimerin-2 Promotes Choroidal Neovascularization. Investigative ophthalmology & visual science, 61(8), 30-30.

Barbera, S., Nardi, F., Elia, I., Realini, G., Lugano, R., Santucci, A., ... & Orlandini, M. (2019). The small GTPase Rab5c is a key regulator of trafficking of the CD93/Multimerin-2/β1 integrin complex in endothelial cell adhesion and migration. Cell Communication and Signaling, 17(1), 1-15.

Lugano, R., Vemuri, K., Yu, D., Bergqvist, M., Smits, A., Essand, M., ... & Dimberg, A. (2018). CD93 promotes β 1 integrin activation and fibronectin fibrillogenesis during tumor angiogenesis. The Journal of clinical investigation, 128(8), 3280-3297.

Griffiths, M. R., Botto, M., Morgan, B. P., Neal, J. W., & Gasque, P. (2018). CD93 regulates central nervous system inflammation in two mouse models of autoimmune encephalomyelitis. Immunology, 155(3), 346-355.

Galvagni, F., Nardi, F., Spiga, O., Trezza, A., Tarticchio, G., Pellicani, R., ... & Orlandini, M. (2017). Dissecting the CD93-Multimerin 2 interaction involved in cell adhesion and migration of the activated endothelium. Matrix Biology, 64, 112-127.

Khan, K. A., Naylor, A. J., Khan, A., Noy, P. J., Mambretti, M., Lodhia, P., ... & Bicknell, R. (2017). Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface. Oncogene, 36(44), 6097-6108.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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