Sign in or Register   Sign in or Register
  |  

Mouse Anti-CDK19 Recombinant Antibody (2C6) (CBMAB-A1394-LY)

The product is antibody recognizes CDC2L6. The antibody 2C6 immunoassay techniques such as: IHC, ELISA.
See all CDK19 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C6
Antibody Isotype
IgG2a, κ
Application
IHC, ELISA

Basic Information

Immunogen
CDC2L6 (NP_055891.1, 1 a.a. ~ 114 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase 19
Introduction
This gene encodes a protein that is one of the components of the Mediator coactivator complex. The Mediator complex is a multiprotein complex required for transcriptional activation by DNA binding transcription factors of genes transcribed by RNA polymerase II. The protein encoded by this gene is similar to cyclin-dependent kinase 8 which can also be a component of the Mediator complex. [provided by RefSeq]
Entrez Gene ID
23097
UniProt ID
Q9BWU1
Alternative Names
CDK11; KIAA1028; bA346C16.3
Biological Process
Cellular response to lipopolysaccharide Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of inflammatory response Source: Ensembl
Protein phosphorylation Source: GO_Central
Cellular Location
Nucleus; Cytoplasm; Perinuclear region
Involvement in disease
Developmental and epileptic encephalopathy 87 (DEE87): A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE87 inheritance is autosomal dominant.

Cai, X., Deng, J., Cai, H., & Chen, Z. (2021). Cyclin Dependent Kinase 19 Upregulation Correlates With Unfavorable Prognosis in Hepatocellular Carcinoma.

Butler, M., Chotiwan, N., Brewster, C. D., DiLisio, J. E., Ackart, D. F., Podell, B. K., ... & Rovnak, J. (2020). Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection. Viruses, 12(6), 654.

Dannappel, M. V., Sooraj, D., Loh, J. J., & Firestein, R. (2019). Molecular and in vivo functions of the CDK8 and CDK19 kinase modules. Frontiers in cell and developmental biology, 6, 171.

Fant, C. B., & Taatjes, D. J. (2019). Regulatory functions of the Mediator kinases CDK8 and CDK19. Transcription, 10(2), 76-90.

Amirhosseini, M., Bernhardsson, M., Lång, P., Andersson, G., Flygare, J., & Fahlgren, A. (2019). Cyclin‐dependent kinase 8/19 inhibition suppresses osteoclastogenesis by downregulating RANK and promotes osteoblast mineralization and cancellous bone healing. Journal of cellular physiology, 234(9), 16503-16516.

Chen, M., Hu, B., Ji, H., Altilia, S., Liang, J., McDermott, M., ... & Roninson, I. (2017). Functional characterization of novel transcription-regulating cancer drug targets, CDK8 and CDK19, using CRISPR/Cas9 knockout and a highly selective CDK8/19 kinase inhibitor.

Audetat, K. A., Galbraith, M. D., Odell, A. T., Lee, T., Pandey, A., Espinosa, J. M., ... & Taatjes, D. J. (2017). A kinase-independent role for cyclin-dependent kinase 19 in p53 response. Molecular and cellular biology, 37(13), e00626-16.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CDK19 Recombinant Antibody (2C6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare