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Mouse Anti-CDC6 Recombinant Antibody (CBYY-C1694) (CBMAB-C3132-YY)

This product is mouse antibody that recognizes CDC6. The antibody CBYY-C1694 can be used for immunoassay techniques such as: IHC-P, WB
See all CDC6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-C1694
Antibody Isotype
IgG1
Application
IHC-P, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Immunoaffinity purified
Buffer
1 mg/mL
Preservative
50% glycerol, 1% BSA, PBS, pH 7.3
Concentration
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cell Division Cycle 6
Entrez Gene ID
990
UniProt ID
Q99741
Alternative Names
Cadherin 11; Cadherin 11, Type 2, OB-Cadherin (Osteoblast); OB-Cadherin; OSF-4; Osteoblast Cadherin; Cadherin-11; CAD11; CDHOB; OB;
Function
Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.
Biological Process
Cell division Source: UniProtKB-KW
Cellular response to angiotensin Source: Ensembl
Cellular response to vasopressin Source: Ensembl
DNA replication Source: Reactome
DNA replication checkpoint Source: ProtInc
DNA replication initiation Source: Reactome
Mitotic cell cycle Source: UniProtKB
Mitotic DNA replication checkpoint Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of DNA replication Source: ProtInc
Positive regulation of chromosome segregation Source: BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
Positive regulation of cytokinesis Source: BHF-UCL
Positive regulation of fibroblast proliferation Source: Ensembl
Pre-replicative complex assembly Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of mitotic metaphase/anaphase transition Source: BHF-UCL
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Traversing start control point of mitotic cell cycle Source: ProtInc
Cellular Location
Nucleus; Cytoplasm. The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).
Involvement in disease
Meier-Gorlin syndrome 5 (MGORS5): A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.

Bömer, M., Pérez‐Salamó, I., Florance, H. V., Salmon, D., Dudenhoffer, J. H., Finch, P., ... & Devoto, A. (2021). Jasmonates induce Arabidopsis bioactivities selectively inhibiting the growth of breast cancer cells through CDC6 and mTOR. New Phytologist, 229(4), 2120-2134.

Chen, X., Ranjan, R., Snedeker, J., Wooten, M., Chu, C., Bracer, S., & Mouton, T. (2021). Differential condensation of sister chromatids coordinates with Cdc6 to ensure distinct cell cycle progression in Drosophila male germline stem cell lineage. bioRxiv.

An, C., Liu, G., Cheng, S., Pang, B., Sun, S., Zhang, Y., ... & Kang, X. (2020). A pilot study of cdc6 as a biomarker for circulating tumor cells in patients with lung cancer. Journal of clinical laboratory analysis, 34(6), e23245.

Zhang, X., Lian, T., Fan, W., Zhang, G., Chen, Z., Gou, X., & Jha, R. K. (2020). Long-Noncoding RNA CASC9 Promotes Progression of Non-Small Cell Lung Cancer by Promoting the Expression of CDC6 Through Binding to HuR. Cancer Management and Research, 12, 9033.

Youn, Y., Lee, J. C., Kim, J., Kim, J. H., & Hwang, J. H. (2020). Cdc6 disruption leads to centrosome abnormalities and chromosome instability in pancreatic cancer cells. Scientific reports, 10(1), 1-11.

Yang, X., & Meng, T. (2020). miR‐215‐5p decreases migration and invasion of trophoblast cells through regulating CDC6 in preeclampsia. Cell biochemistry and function, 38(4), 472-479.

Dębowski, M., Szymańska, Z., Kubiak, J. Z., & Lachowicz, M. (2019). Mathematical model explaining the role of CDC6 in the diauxic growth of CDK1 activity during the M-Phase of the cell cycle. Cells, 8(12), 1537.

Kong, X., Duan, Y., Sang, Y., Li, Y., Zhang, H., Liang, Y., ... & Yang, Q. (2019). LncRNA–CDC6 promotes breast cancer progression and function as ceRNA to target CDC6 by sponging microRNA‐215. Journal of cellular physiology, 234(6), 9105-9117.

Zhang, J. H., He, Y. L., Zhu, R., Du, W., & Xiao, J. H. (2017). Deregulated expression of Cdc6 as BCR/ABL-dependent survival factor in chronic myeloid leukemia cells. Tumor Biology, 39(6), 1010428317713394.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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