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Rabbit Anti-CDCA2 Recombinant Antibody (EG575) (CBMAB-EN694-LY)

The product is antibody recognizes CDCA2. The antibody EG575 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all CDCA2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG575
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from C-terminal of human CDCA2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cell Division Cycle Associated 2
Introduction
CDCA2 (Cell Division Cycle Associated 2) is a Protein Coding gene. Among its related pathways are DNA Damage.
Entrez Gene ID
157313
UniProt ID
Q99618
Alternative Names
Cell Division Cycle Associated 2; Recruits PP1 Onto Mitotic Chromatin At Anaphase Protein; Protein Phosphatase 1, Regulatory Subunit 81; Repo-Man; Cell Division Cycle-Associated Protein 2; PPP1R81;
Function
Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.
Biological Process
Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Chromosome segregation Source: Ensembl
Positive regulation of protein dephosphorylation Source: MGI
Cellular Location
Nucleus. Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.
PTM
Phosphorylated by CDK1. May regulate its subcellular location.

Xu, B., Chen, H., Xu, Z., Yao, X., Sun, X., & Cheng, H. (2021). CDCA2 promotes tumorigenesis and induces radioresistance in oesophageal squamous cell carcinoma cells. Molecular Medicine Reports, 24(1), 1-10.

Li, J., Chen, Y., Wang, X., & Wang, C. (2021). CDCA2 triggers in vivo and in vitro proliferation of hepatocellular carcinoma by activating the AKT/CCND1 signaling. Journal of BU ON.: Official Journal of the Balkan Union of Oncology, 26(3), 882-888.

Li, F., Zhang, H., Li, Q., Wu, F., Wang, Y., Wang, Z., ... & Huang, C. (2020). CDCA2 acts as an oncogene and induces proliferation of clear cell renal cell carcinoma cells. Oncology letters, 19(3), 2466-2474.

Zhang, Y., Cheng, Y., Zhang, Z., Bai, Z., Jin, H., Guo, X., ... & Ying, Y. (2020). CDCA2 Inhibits Apoptosis and Promotes Cell Proliferation in Prostate Cancer and Is Directly Regulated by HIF-1α Pathway. Frontiers in oncology, 10, 725.

Jin, W. H., Zhou, A. T., Chen, J. J., & Cen, Y. (2020). CDCA2 promotes proliferation and migration of melanoma by upregulating CCAD1. European Review for Medical and Pharmacological Sciences, 24(12), 6858-6863.

Feng, Y., Qian, W., Zhang, Y., Peng, W., Li, J., Gu, Q., ... & Sun, Y. (2019). CDCA2 promotes the proliferation of colorectal cancer cells by activating the AKT/CCND1 pathway in vitro and in vivo. BMC cancer, 19(1), 1-11.

Shi, R., Zhang, C., Wu, Y., Wang, X., Sun, Q., Sun, J., ... & Xu, L. (2017). CDCA2 promotes lung adenocarcinoma cell proliferation and predicts poor survival in lung adenocarcinoma patients. Oncotarget, 8(12), 19768.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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