CDCA2

CDCA2 (Cell Division Cycle Associated 2) is a Protein Coding gene. Among its related pathways are DNA Damage.

Full Name

Cell Division Cycle Associated 2

Function

Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell division Source: UniProtKB-KW
Chromosome segregation Source: Ensembl
Positive regulation of protein dephosphorylation Source: MGI

Cellular Location

Nucleus. Excluded from the nucleolus. Present in nucleoplasm throughout the G1, S and G2 stages of the cell cycle. During M phase, it becomes diffuse throughout the cell as the nuclear membrane breaks down, and faintly accumulates later on metaphase chromatin. As the cell progresses to anaphase, it accumulates on chromatin.

PTM

Phosphorylated by CDK1. May regulate its subcellular location.