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Mouse Anti-CDHR3 Recombinant Antibody (8E8) (CBMAB-C2085-CN)

This product is a Mouse antibody that recognizes CDHR3. The antibody 8E8 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all CDHR3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
8E8
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
Partial recombinant protein corresponding to aa 776-885 from human FLJ23834 (NP_689963) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4

Target

Full Name
Cadherin Related Family Member 3
Introduction
CDHR3 (Cadherin Related Family Member 3) is a Protein Coding gene. Diseases associated with CDHR3 include Asthma. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR4.
Entrez Gene ID
222256
UniProt ID
Q6ZTQ4
Alternative Names
Cadherin Related Family Member 3; Cadherin-Related Family Member 3; Cadherin-Like Protein 28; CDH28;
Function
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
(Microbial infection) Acts as a receptor for rhinovirus C.
Biological Process
Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
Asthma susceptibility may be associated with variants affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age.
Topology
Extracellular: 20-713
Helical: 714-734
Cytoplasmic: 735-885

Nakagome, K., Shimizu, T., Bochkov, Y., Noguchi, T., Kobayashi, T., Soma, T., ... & Nagata, M. (2020). Transfection with Cadherin-related Family Member 3 Variant Increases Eosinophil Adhesion to Transfected Cells and Superoxide Anion Generation. Journal of Allergy and Clinical Immunology, 145(2), AB91.

Nakagome, K., Shimizu, T., Bochkov, Y. A., Noguchi, T., Kobayashi, T., Soma, T., ... & Nagata, M. (2020). Cadherin-related family member 3 upregulates the effector functions of eosinophils. Allergy, 75(7), 1805.

Leung, T. F., Tang, M. F., Leung, A. S. Y., Kong, A. P. S., Liu, T. C., Chan, R. W. Y., ... & Wong, G. W. K. (2020). Cadherin‐related family member 3 gene impacts childhood asthma in Chinese children. Pediatric Allergy and Immunology, 31(2), 133-142.

Sun, Y., Watters, K., Hill, M. G., Fang, Q., Liu, Y., Kuhn, R. J., ... & Palmenberg, A. C. (2020). Cryo-EM structure of rhinovirus C15a bound to its cadherin-related protein 3 receptor. Proceedings of the National Academy of Sciences, 117(12), 6784-6791.

Lutter, R., & Ravanetti, L. (2019). Cadherin-related family member 3 (CDHR3) drives differentiation of ciliated bronchial epithelial cells and facilitates rhinovirus C infection, although with a little help. Journal of Allergy and Clinical Immunology, 144(4), 926-927.

Bønnelykke, K., Coleman, A. T., Evans, M. D., Thorsen, J., Waage, J., Vissing, N. H., ... & Bisgaard, H. (2018). Cadherin-related family member 3 genetics and rhinovirus C respiratory illnesses. American journal of respiratory and critical care medicine, 197(5), 589-594.

Watters, K., & Palmenberg, A. C. (2018). CDHR3 extracellular domains EC1-3 mediate rhinovirus C interaction with cells and as recombinant derivatives, are inhibitory to virus infection. PLoS pathogens, 14(12), e1007477.

Stenberg Hammar, K., Niespodziana, K., van Hage, M., Kere, J., Valenta, R., Hedlin, G., & Söderhäll, C. (2018). Reduced CDHR 3 expression in children wheezing with rhinovirus. Pediatric Allergy and Immunology, 29(2), 200-206.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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