CDHR3

CDHR3 (Cadherin Related Family Member 3) is a Protein Coding gene. Diseases associated with CDHR3 include Asthma. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is CDHR4.

Full Name

Cadherin Related Family Member 3

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
(Microbial infection) Acts as a receptor for rhinovirus C.

Biological Process

Adherens junction organization Source: GO_Central
Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
Cell-cell adhesion via plasma-membrane adhesion molecules Source: GO_Central
Cell-cell junction assembly Source: GO_Central
Cell morphogenesis Source: GO_Central
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: GO_Central

Cellular Location

Cell membrane

Involvement in disease

Asthma susceptibility may be associated with variants affecting the gene represented in this entry in early childhood asthma with severe exacerbations occurring between 2 and 6 years of age.

Topology

Extracellular: 20-713
Helical: 714-734
Cytoplasmic: 735-885