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Rabbit Anti-CDK10 Recombinant Antibody (D8Z7Z) (CBMAB-CP0261-LY)

The product is antibody recognizes CDK10. The antibody D8Z7Z immunoassay techniques such as: WB.
See all CDK10 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
D8Z7Z
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val24 of human CDK10 protein.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase 10
Introduction
CDK10 (Cyclin Dependent Kinase 10) is a Protein Coding gene. Diseases associated with CDK10 include Al Kaissi Syndrome and Tick Infestation. Among its related pathways are DNA Damage and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11A.
Entrez Gene ID
Human8558
Mouse234854
Rat361434
UniProt ID
HumanQ15131
MouseQ3UMM4
RatQ4KM47
Alternative Names
Cyclin Dependent Kinase 10; Cyclin-Dependent Kinase (CDC2-Like) 10; Cell Division Protein Kinase 10; EC 2.7.11.22; Cyclin-Dependent Kinase Related Protein; Serine/Threonine Protein Kinase PISSLRE; Serine/Threonine-Protein Kinase PISSLRE;
Function
Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572).
Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).
Biological Process
Cell projection organization Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of cilium assembly Source: UniProtKB
Peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of MAPK cascade Source: Ensembl
Protein phosphorylation Source: GO_Central
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Traversing start control point of mitotic cell cycle Source: ProtInc
Cellular Location
Cilium basal body
Involvement in disease
Al Kaissi syndrome (ALKAS): An autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay.

Bazzi, Z. A., & Tai, I. T. (2021). CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene. Frontiers in Oncology, 11.

Mamoor, S. (2020). Significant up-regulation of the cyclin-dependent kinase CDK10 in primary tumors of patients treated with trastuzumab.

Robert, T., Johnson, J. L., Guichaoua, R., Yaron, T. M., Bach, S., Cantley, L. C., & Colas, P. (2020). Development of a CDK10/CycM in vitro kinase screening assay and identification of first small-molecule inhibitors. Frontiers in chemistry, 8, 147.

Zehra, M., Mushtaq, S., Musharraf, S. G., Ghani, R., & Ahmed, N. (2019). Association of cyclin dependent kinase 10 and transcription factor 2 during human corneal epithelial wound healing in vitro model. Scientific reports, 9(1), 1-12.

Guen, V. J., Edvardson, S., Fraenkel, N. D., Fattal‐Valevski, A., Jalas, C., Anteby, I., ... & Elpeleg, O. (2018). A homozygous deleterious CDK10 mutation in a patient with agenesis of corpus callosum, retinopathy, and deafness. American Journal of Medical Genetics Part A, 176(1), 92-98.

Qureshi, M. F. H., Lakhani, M., Shah, M., & Mushtaq, S. (2018). CELL CYCLE REGULATOR: CYCLIN DEPENDENT KINASE 10 AS POTENTIAL TARGET IN CANCER. The Pakistan Journal of Medicine and Dentistry, 7(4), 5-5.

You, Y., Bai, F., Ye, Z., Zhang, N., Yao, L., Tang, Y., & Li, X. (2018). Downregulated CDK10 expression in gastric cancer: Association with tumor progression and poor prognosis. Molecular medicine reports, 17(5), 6812-6818.

Li, H., You, Y., & Liu, J. (2018). Cyclin‑dependent kinase 10 prevents glioma metastasis via modulation of Snail expression. Molecular medicine reports, 18(1), 1165-1170.

Mishra, T., Shukla, S., Meena, S., Singh, R., Pal, M., Upreti, D. K., & Datta, D. (2017). Isolation and identification of cytotoxic compounds from a fruticose lichen Roccella montagnei, and it’s in silico docking study against CDK-10. Revista Brasileira de Farmacognosia, 27(6), 724-728.

Zhao, B. W., Chen, S., Li, Y. F., Xiang, J., Zhou, Z. W., Peng, J. S., & Chen, Y. B. (2017). Low expression of CDK10 correlates with adverse prognosis in gastric carcinoma. Journal of Cancer, 8(15), 2907.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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