CDK10

CDK10 (Cyclin Dependent Kinase 10) is a Protein Coding gene. Diseases associated with CDK10 include Al Kaissi Syndrome and Tick Infestation. Among its related pathways are DNA Damage and Cell Cycle Control of Chromosomal Replication. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDK11A.

Full Name

Cyclin Dependent Kinase 10

Function

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572).
Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747).

Biological Process

Cell projection organization Source: UniProtKB-KW
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of cilium assembly Source: UniProtKB
Peptidyl-threonine phosphorylation Source: UniProtKB
Positive regulation of MAPK cascade Source: Ensembl
Protein phosphorylation Source: GO_Central
Regulation of actin cytoskeleton organization Source: UniProtKB
Regulation of mitotic cell cycle Source: GO_Central
Traversing start control point of mitotic cell cycle Source: ProtInc

Cellular Location

Cilium basal body

Involvement in disease

Al Kaissi syndrome (ALKAS): An autosomal recessive developmental disorder characterized by growth retardation, spine malformation, facial dysmorphisms, and developmental delay.