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Mouse Anti-CDK13 Recombinant Antibody (10B2175) (CBMAB-C2159-LY)

This product is antibody recognizes CDK13. The antibody 10B2175 immunoassay techniques such as: ELISA, IHC-F, WB.
See all CDK13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
10B2175
Antibody Isotype
IgG1
Application
ELISA, IHC-F, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
0.5 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cyclin Dependent Kinase 13
Introduction
CDK13 (Cyclin Dependent Kinase 13) is a Protein Coding gene.
Diseases associated with CDK13 include Congenital Heart Defects, Dysmorphic Facial Features, And Intellectual Developmental Disorder and Corneal Endothelial Dystrophy.
Among its related pathways are Innate Immune System and Gene Expression.
Gene Ontology (GO) annotations related to this gene include protein kinase activity.
An important paralog of this gene is CDK12.
Entrez Gene ID
8621
UniProt ID
Q14004
Alternative Names
Cyclin Dependent Kinase 13; Cholinesterase-Related Cell Division Controller; Cell Division Cycle 2-Like Protein Kinase 5; Cell Division Protein Kinase 13; CDC2-Related Protein Kinase 5; EC 2.7.11.22; CDC2L5; HCDK13; CDC2L;
Function
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
Biological Process
Alternative mRNA splicing, via spliceosome Source: UniProtKB
Hemopoiesis Source: UniProtKB
Multicellular organism development Source: ProtInc
Negative regulation of stem cell differentiation Source: Ensembl
Neutrophil degranulation Source: Reactome
Phosphorylation of RNA polymerase II C-terminal domain Source: UniProtKB
Positive regulation of cell population proliferation Source: ProtInc
Positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
Protein phosphorylation Source: GO_Central
Regulation of mitotic nuclear division Source: ProtInc
Transcription elongation from RNA polymerase II promoter Source: GO_Central
Viral process Source: UniProtKB-KW
Cellular Location
Nucleus speckle
Involvement in disease
Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD): An autosomal dominant syndrome characterized by atrial and/or ventricular septal congenital heart defects, facial dysmorphism with hypertelorism, upslanted palpebral fissures, epicanthal folds, ptosis, strabismus, posteriorly rotated ears, thin upper lip, and small mouth. Patients manifest global developmental delay, delayed walking and speech acquisition, and intellectual disability. Some patients have mild microcephaly, a small cerebral cortex, and agenesis of corpus callosum. More variable features include clinodactyly and/or camptodactyly of the fingers, hypotonia, and joint hypermobility.

Ramírez-Moya, J., Miliotis, C., Baker, A. R., Gregory, R. I., Slack, F. J., & Santisteban, P. (2021). An ADAR1-dependent RNA editing event in the cyclin-dependent kinase CDK13 promotes thyroid cancer hallmarks. Molecular cancer, 20(1), 1-20.

Wang, J., Zhang, Y., Lu, L., Lu, Y., Tang, Q., & Pu, J. (2019). Insight into the molecular mechanism of LINC00152/miR‐215/CDK13 axis in hepatocellular carcinoma progression. Journal of cellular biochemistry, 120(11), 18816-18825.

Baniya, S. (2019). Validating CDK13 as a Novel Dependency in Acute Myeloid Leukemia (Doctoral dissertation, Wellesley College).

Hamilton, M. J., & Suri, M. (2019). CDK13-related disorder. Advances in genetics, 103, 163-182.

Hampl, M., Novakova, M., Kavkova, M., Zikmund, T., Kohoutek, J., Kaiser, J., & Buchtová, M. (2019). Cdk13-/-Mice Exhibit Developmental Delay and Craniofacial Malformations during Embryonic Development.

Quereda, V., Bayle, S., Vena, F., Frydman, S. M., Monastyrskyi, A., Roush, W. R., & Duckett, D. R. (2019). Therapeutic targeting of CDK12/CDK13 in triple-negative breast cancer. Cancer Cell, 36(5), 545-558.

van den Akker, W. M. R., Brummelman, I., Martis, L. M., Timmermans, R. N., Pfundt, R., Kleefstra, T., ... & Schuurs‐Hoeijmakers, J. H. M. (2018). De novo variants in CDK13 associated with syndromic ID/DD: molecular and clinical delineation of 15 individuals and a further review. Clinical genetics, 93(5), 1000-1007.

Uehara, T., Takenouchi, T., Kosaki, R., Kurosawa, K., Mizuno, S., & Kosaki, K. (2018). Redefining the phenotypic spectrum of de novo heterozygous CDK13 variants: Three patients without cardiac defects. European journal of medical genetics, 61(5), 243-247.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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