Mouse Anti-CDK2AP1 Recombinant Antibody (2140D5a) (CBMAB-C0621-LY)

This product is antibody recognizes CDK2AP1. The antibody 2140D5a immunoassay techniques such as: DB, ICC, IF, WB.
See all CDK2AP1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

2140D5a

Antibody Isotype

IgG1

Application

DB, ICC, IF, WB

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

1% BSA

Preservative

0.05% sodium azide

Concentration

0.1 mg/ml

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Cyclin Dependent Kinase 2 Associated Protein 1

Introduction

CDK2AP1 (Cyclin Dependent Kinase 2 Associated Protein 1) is a Protein Coding gene. Diseases associated with CDK2AP1 include Oral Cancer. Gene Ontology (GO) annotations related to this gene include DNA polymerase binding. An important paralog of this gene is CDK2AP2.

Entrez Gene ID

8099

UniProt ID

O14519

Alternative Names

Cyclin Dependent Kinase 2 Associated Protein 1; CDK2-Associated Protein 1; Putative Oral Cancer Suppressor; Deleted In Oral Cancer 1; Doc-1; DOC1; Cyclin-Dependent Kinase 2-Associated Protein 1;

Function

Specific inhibitor of the cell-cycle kinase CDK2.

Biological Process

Cell cycle Source: UniProtKB-KW
DNA-dependent DNA replication Source: UniProtKB
Positive regulation of protein phosphorylation Source: UniProtKB

Cellular Location

Cytosol; Nucleoplasm; Nucleus; Perinuclear region of cytoplasm

PTM

Phosphorylated in vitro by IKBKE at Ser-46.

References

Sahu, S. N., Satpathy, S. S., Mohanty, C., & Pattanayak, S. K. (2021). Computational study to evaluate the potency of phytochemicals in Boerhavia diffusa and the impact of point mutation on cyclin-dependent kinase 2-associated protein 1. Journal of Biomolecular Structure and Dynamics, 1-15.

Modzelewski, A. J., Shao, W., Chen, J., Lee, A., Qi, X., Noon, M., ... & He, L. (2021). A mouse-specific retrotransposon drives a conserved Cdk2ap1 isoform essential for development. Cell, 184(22), 5541-5558.

Li, Q. S., & De Muynck, L. (2021). Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1. Brain, Behavior, & Immunity-Health, 13, 100227.

Wang, Z., Xiang, Z., Zhu, T., Chen, J., Zhong, M. Z., Huang, J., ... & Zhou, W. B. (2020). Cathepsin L interacts with CDK2‑AP1 as a potential predictor of prognosis in patients with breast cancer. Oncology letters, 19(1), 167-176.

Gera, R., Mokbel, L., Jiang, W. G., & Mokbel, K. (2018). mRNA expression of CDK2AP1 in human breast cancer: Correlation with clinical and pathological parameters. Cancer genomics & proteomics, 15(6), 447-452.

Alsayegh, K. N., Sheridan, S. D., Iyer, S., & Rao, R. R. (2018). Knockdown of CDK2AP1 in human embryonic stem cells reduces the threshold of differentiation. PloS one, 13(5), e0196817.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CDK2AP1 Recombinant Antibody (CBXC-1742)

Rabbit Anti-CDK2AP1 Recombinant Antibody (EG618)

Mouse Anti-CDK2AP1 Recombinant Antibody (CBFYC-1597)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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