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Rabbit Anti-CDO1 Recombinant Antibody (CBYY-C1823) (CBMAB-C3261-YY)

This product is rabbit antibody that recognizes CDO1. The antibody CBYY-C1823 can be used for immunoassay techniques such as: ELISA
See all CDO1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYY-C1823
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Human CDON protein. This antibody was obtained from a rabbit immunized with purified, recombinant Human CDON
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Affinity purified
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Cysteine Dioxygenase Type 1
Entrez Gene ID
1036
UniProt ID
Q16878
Alternative Names
CD66e, CEA
Function
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
Biological Process
Cysteine metabolic process Source: UniProtKB
Inflammatory response Source: UniProtKB
Lactation Source: Ensembl
L-cysteine catabolic process Source: GO_Central
Response to amino acid Source: Ensembl
Response to cAMP Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucagon Source: Ensembl
Response to glucocorticoid Source: Ensembl
Sulfur amino acid biosynthetic process Source: UniProtKB
Taurine biosynthetic process Source: UniProtKB
Cellular Location
Cytosol
PTM
The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.

Dawson, P. A., Weerasekera, S. J., Atcheson, R. J., Twomey, S. A., & Simmons, D. G. (2020). Molecular analysis of the human placental cysteine dioxygenase type 1 gene. Molecular genetics and metabolism reports, 22, 100568.

Fujiyama, Y., Kumamoto, Y., Nishizawa, N., Nakamoto, S., Harada, H., Yokota, K., ... & Yamashita, K. (2020). Promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in intraductal papillary mucinous neoplasm (IPMN). Annals of surgical oncology, 27(10), 4007-4016.

Kang, Y. P., Torrente, L., Falzone, A., Elkins, C. M., Liu, M., Asara, J. M., ... & DeNicola, G. M. (2019). Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Elife, 8, e45572.

Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Ushiku, H., ... & Yamashita, K. (2019). Cancer-specific promoter DNA methylation of Cysteine dioxygenase type 1 (CDO1) gene as an important prognostic biomarker of gastric cancer. Plos one, 14(4), e0214872.

Nishizawa, N., Harada, H., Kumamoto, Y., Kaizu, T., Katoh, H., Tajima, H., ... & Yamashita, K. (2019). Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO 1) promoter DNA in pancreatic cancer. Cancer science, 110(9), 2846-2855.

Kojima, K., Nakamura, T., Ohbu, M., Katoh, H., Ooizumi, Y., Igarashi, K., ... & Yamashita, K. (2018). Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer. PLoS One, 13(5), e0194785.

Kojima, K., Yamashita, K., Ushiku, H., Katoh, H., Ishii, S., Tanaka, T., ... & Watanabe, M. (2017). The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma. Diseases of the Esophagus, 30(3).

Hao, S., Yu, J., He, W., Huang, Q., Zhao, Y., Liang, B., ... & Shi, M. (2017). Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells. Neoplasia, 19(12), 1022-1032.

Igarashi, K., Yamashita, K., Katoh, H., Kojima, K., Ooizumi, Y., Nishizawa, N., ... & Watanabe, M. (2017). Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. PLoS One, 12(11), e0188178.

Choi, J. I., Cho, E. H., Kim, S. B., Kim, R., Kwon, J., Park, M., ... & Lee, K. H. (2017). Promoter methylation of cysteine dioxygenase type 1: gene silencing and tumorigenesis in hepatocellular carcinoma. Annals of Hepato-biliary-pancreatic Surgery, 21(4), 181-187.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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