CDO1

CDO1 (Cysteine Dioxygenase Type 1) is a Protein Coding gene. Diseases associated with CDO1 include Hepatoblastoma and Esophagus Adenocarcinoma. Among its related pathways are Viral mRNA Translation and Metabolism. Gene Ontology (GO) annotations related to this gene include iron ion binding and cysteamine dioxygenase activity.

Full Name

Cysteine Dioxygenase Type 1

Function

Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.

Biological Process

Cysteine metabolic process Source: UniProtKB
Inflammatory response Source: UniProtKB
Lactation Source: Ensembl
L-cysteine catabolic process Source: GO_Central
Response to amino acid Source: Ensembl
Response to cAMP Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucagon Source: Ensembl
Response to glucocorticoid Source: Ensembl
Sulfur amino acid biosynthetic process Source: UniProtKB
Taurine biosynthetic process Source: UniProtKB

Cellular Location

Cytosol

PTM

The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.