Human CDO1 ELISA Kit (V2LY-0626-LY4463)

See all CDO1 antibodies
Go to compare Compare Online Inquiry
Tested Data
Datasheet
SDS
Request for COA
Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.01 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
23.0 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Cysteine Dioxygenase Type 1
Function
Initiates several important metabolic pathways related to pyruvate and several sulfurate compounds including sulfate, hypotaurine and taurine. Critical regulator of cellular cysteine concentrations. Has an important role in maintaining the hepatic concentation of intracellular free cysteine within a proper narrow range.
Biological Process
Cysteine metabolic process Source: UniProtKB
Inflammatory response Source: UniProtKB
Lactation Source: Ensembl
L-cysteine catabolic process Source: GO_Central
Response to amino acid Source: Ensembl
Response to cAMP Source: Ensembl
Response to ethanol Source: Ensembl
Response to glucagon Source: Ensembl
Response to glucocorticoid Source: Ensembl
Sulfur amino acid biosynthetic process Source: UniProtKB
Taurine biosynthetic process Source: UniProtKB
Cellular Location
Cytosol
PTM
The thioether cross-link between Cys-93 and Tyr-157 plays a structural role through stabilizing the Fe2+ ion, and prevents the production of highly damaging free hydroxyl radicals by holding the oxygen radical via hydroxyl hydrogen.

Dawson, P. A., Weerasekera, S. J., Atcheson, R. J., Twomey, S. A., & Simmons, D. G. (2020). Molecular analysis of the human placental cysteine dioxygenase type 1 gene. Molecular genetics and metabolism reports, 22, 100568.

Fujiyama, Y., Kumamoto, Y., Nishizawa, N., Nakamoto, S., Harada, H., Yokota, K., ... & Yamashita, K. (2020). Promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in intraductal papillary mucinous neoplasm (IPMN). Annals of surgical oncology, 27(10), 4007-4016.

Kang, Y. P., Torrente, L., Falzone, A., Elkins, C. M., Liu, M., Asara, J. M., ... & DeNicola, G. M. (2019). Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer. Elife, 8, e45572.

Harada, H., Hosoda, K., Moriya, H., Mieno, H., Ema, A., Ushiku, H., ... & Yamashita, K. (2019). Cancer-specific promoter DNA methylation of Cysteine dioxygenase type 1 (CDO1) gene as an important prognostic biomarker of gastric cancer. Plos one, 14(4), e0214872.

Nishizawa, N., Harada, H., Kumamoto, Y., Kaizu, T., Katoh, H., Tajima, H., ... & Yamashita, K. (2019). Diagnostic potential of hypermethylation of the cysteine dioxygenase 1 gene (CDO 1) promoter DNA in pancreatic cancer. Cancer science, 110(9), 2846-2855.

Kojima, K., Nakamura, T., Ohbu, M., Katoh, H., Ooizumi, Y., Igarashi, K., ... & Yamashita, K. (2018). Cysteine dioxygenase type 1 (CDO1) gene promoter methylation during the adenoma-carcinoma sequence in colorectal cancer. PLoS One, 13(5), e0194785.

Kojima, K., Yamashita, K., Ushiku, H., Katoh, H., Ishii, S., Tanaka, T., ... & Watanabe, M. (2017). The clinical significance of cysteine dioxygenase type 1 methylation in Barrett esophagus adenocarcinoma. Diseases of the Esophagus, 30(3).

Hao, S., Yu, J., He, W., Huang, Q., Zhao, Y., Liang, B., ... & Shi, M. (2017). Cysteine dioxygenase 1 mediates erastin-induced ferroptosis in human gastric cancer cells. Neoplasia, 19(12), 1022-1032.

Igarashi, K., Yamashita, K., Katoh, H., Kojima, K., Ooizumi, Y., Nishizawa, N., ... & Watanabe, M. (2017). Prognostic significance of promoter DNA hypermethylation of the cysteine dioxygenase 1 (CDO1) gene in primary gallbladder cancer and gallbladder disease. PLoS One, 12(11), e0188178.

Choi, J. I., Cho, E. H., Kim, S. B., Kim, R., Kwon, J., Park, M., ... & Lee, K. H. (2017). Promoter methylation of cysteine dioxygenase type 1: gene silencing and tumorigenesis in hepatocellular carcinoma. Annals of Hepato-biliary-pancreatic Surgery, 21(4), 181-187.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Human CDO1 ELISA Kit?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CDO protein, His Tag (CAT#: V2LY-0526-LY3076)

Related Products

Mouse Anti-CDO1 Recombinant Antibody (CBYY-C1822) (CAT#: CBMAB-C3260-YY)

Human Recombinant CDO protein, His Tag (CAT#: V2LY-0526-LY3076)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry
Request bulk or custom quote Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.