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Rat Anti-EMCN Recombinant Antibody (eBioV.7C7 V.7C7) (CBMAB-E0280-FY)

This product is rat antibody that recognizes EMCN. The antibody eBioV.7C7 V.7C7 can be used for immunoassay techniques such as: FC, IHC-P, IP, WB.
See all EMCN antibodies
Published Data
Fig.1 The correlation of HMGA2 expression with VM in clinical samples.
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Fig.2 Western blot showed the protein expression of MMP2 in GC cells.
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Fig.3 EDV with Endomucin expression in a xenograft tumour model.
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Summary

Host Animal
Rat
Specificity
Mouse
Clone
eBioV.7C7 V.7C7
Antibody Isotype
IgG2a
Application
FC, IHC-P, IP, WB

Basic Information

Specificity
Mouse
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Preservative
0.09% Sodium azide
Concentration
0.5 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ENDOMUCIN
Introduction
EMCN is a mucin-like sialoglycoprotein that interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (Kinoshita et al., 2001).
Entrez Gene ID
59308
UniProt ID
Q9R0H2
Alternative Names
Muc14; AI315669; 0610012K22Rik
Research Area
Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix.
Biological Process
Hematopoietic stem cell homeostasis Source: Ensembl
Cellular Location
Isoform 1: Cell membrane; Membrane. Consistently localized to the plasma membrane and less abundantly to Golgi-like perinuclear stacks.
Isoform 2: Secreted
Topology
Extracellular: 19-190
Helical: 191-211
Cytoplasmic: 212-261
PTM
Highly O-glycosylated. Sialic acid-rich glycoprotein.

Huang, Q., Li, X. M., Sun, J. P., & Zhou, Y. (2022). Tumor‐derived endomucin promotes colorectal cancer proliferation and metastasis. Cancer Medicine.

Shen, Z., Dong, W., Chen, Z., Chen, G., Zhang, Y., Li, Z., ... & Jiang, Z. (2022). Total flavonoids of Rhizoma Drynariae enhances CD31 hi Emcn hi vessel formation and subsequent bone regeneration in rat models of distraction osteogenesis by activating PDGF‑BB/VEGF/RUNX2/OSX signaling axis. International Journal of Molecular Medicine, 50(3), 1-13.

Engelhard, S., Drilsvik, M., Gonzalez, F. R., Nerlov, C., Weischenfeldt, J., Reckzeh, K., & Theilgaard-Mönch, K. (2022). P1403: ENDOMUCIN IS A MARKER OF QUIESCENT HAEMATOPOIETIC STEM CELLS WITH HIGH LONG-TERM ENGRAFTMENT CAPACITY. HemaSphere, 6, 1287-1288.

Zhang, P., Yue, K., Liu, X., Yan, X., Yang, Z., Duan, J., ... & Han, H. (2020). Endothelial Notch activation promotes neutrophil transmigration via downregulating endomucin to aggravate hepatic ischemia/reperfusion injury. Science China Life Sciences, 63(3), 375-387.

Yang, J., LeBlanc, M. E., Cano, I., Saez-Torres, K. L., Saint-Geniez, M., Ng, Y. S., & D'Amore, P. A. (2020). ADAM10 and ADAM17 proteases mediate proinflammatory cytokine-induced and constitutive cleavage of endomucin from the endothelial surface. Journal of Biological Chemistry, 295(19), 6641-6651.

Yang, M., Li, C. J., Xiao, Y., Guo, Q., Huang, Y., Su, T., ... & Jiang, T. J. (2020). Ophiopogonin D promotes bone regeneration by stimulating CD31hiEMCNhi vessel formation. Cell proliferation, 53(3), e12784.

Hu, Z., Cano, I., Saez-Torres, K. L., LeBlanc, M. E., Saint-Geniez, M., Ng, Y. S., ... & D’Amore, P. A. (2020). Elements of the endomucin extracellular domain essential for VEGF-induced VEGFR2 activity. Cells, 9(6), 1413.

Niu, T., Zhao, M., Jiang, Y., Xing, X., Shi, X., Cheng, L., ... & Liu, K. (2019). Endomucin restores depleted endothelial glycocalyx in the retinas of streptozotocin‐induced diabetic rats. The FASEB Journal, 33(12), 13346-13357.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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