Mouse Anti-CDSN Recombinant Antibody (6F11) (CBMAB-C8259-LY)

Name: Mouse Anti-CDSN Recombinant Antibody (6F11)
SKU: CBMAB-C8259-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

6F11

Application

ELISA, WB

Immunogen

CDSN (306 a.a. ~ 355 a.a) partial recombinant protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

corneodesmosin

Introduction

This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6. [provided by RefSeq, Dec 2014]

Entrez Gene ID

1041

UniProt ID

Q15517

Alternative Names

Corneodesmosin; Differentiated Keratinocyte S Protein; S Protein; HTSS1; HYPT2; PSS1; HTSS; PSS; S;

Function

Important for the epidermal barrier integrity.

Biological Process

Cell adhesion Source: ProtInc
Cell-cell adhesion Source: MGI
Corneocyte desquamation Source: CAFA
Cornification Source: Reactome
Epidermis development Source: ProtInc
Keratinocyte differentiation Source: UniProtKB
Negative regulation of cornification Source: CAFA
Skin morphogenesis Source: UniProtKB

Cellular Location

Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.

Involvement in disease

Hypotrichosis 2 (HYPT2): A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. HYPT2 inheritance is autosomal dominant.
Peeling skin syndrome 1 (PSS1): A genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels.

Towell, A. M., Feuillie, C., Vitry, P., Da Costa, T. M., Mathelié-Guinlet, M., Kezic, S., ... & Geoghegan, J. A. (2021). Staphylococcus aureus binds to the N-terminal region of corneodesmosin to adhere to the stratum corneum in atopic dermatitis. Proceedings of the National Academy of Sciences, 118(1).

Pin, D., Pendaries, V., Keita Alassane, S., Froment, C., Amalric, N., Cadiergues, M. C., ... & Simon, M. (2019). Refined immunochemical characterization in healthy dog skin of the epidermal cornification proteins, filaggrin, and corneodesmosin. Journal of Histochemistry & Cytochemistry, 67(2), 85-97.

Koizumi, H., Kawaguchi, R., Ohkubo, J. I., Ikezaki, S., Kitamura, T., Hohchi, N., ... & Suzuki, H. (2017). Expressions of isopeptide bonds and corneodesmosin in middle ear cholesteatoma. Clinical Otolaryngology, 42(2), 252-262.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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