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Mouse Anti-CDSN Recombinant Antibody (CBFYH-0068) (CBMAB-H0890-FY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBFYH-0068
Antibody Isotype
IgG1, κ
Application
ELISA, WB, IF, IP

Basic Information

Immunogen
Amino acids 204-227 within an internal region of CDSN of mouse.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
corneodesmosin
Introduction
This gene encodes a protein found in corneodesmosomes, which localize to human epidermis and other cornified squamous epithelia. The encoded protein undergoes a series of cleavages during corneocyte maturation. This gene is highly polymorphic in human populations, and variation has been associated with skin diseases such as psoriasis, hypotrichosis and peeling skin syndrome. The gene is located in the major histocompatibility complex (MHC) class I region on chromosome 6.
Entrez Gene ID
1041
UniProt ID
Q15517
Alternative Names
Corneodesmosin; Differentiated Keratinocyte S Protein; S Protein; HTSS1; HYPT2; PSS1; HTSS; PSS; S
Function
Important for the epidermal barrier integrity.
Biological Process
Cell adhesion Source: ProtInc
Cell-cell adhesion Source: MGI
Corneocyte desquamation Source: CAFA
Cornification Source: Reactome
Epidermis development Source: ProtInc
Keratinocyte differentiation Source: UniProtKB
Negative regulation of cornification Source: CAFA
Skin morphogenesis Source: UniProtKB
Cellular Location
Secreted. Found in corneodesmosomes, the intercellular structures that are involved in desquamation.
Involvement in disease
Hypotrichosis 2 (HYPT2): A condition characterized by the presence of less than the normal amount of hair. Affected individuals have normal hair in early childhood but experience progressive hair loss limited to the scalp beginning in the middle of the first decade and almost complete baldness by the third decade. Body hair, beard, eyebrows, axillary hair, teeth, and nails develop normally. HYPT2 inheritance is autosomal dominant.
Peeling skin syndrome 1 (PSS1): A genodermatosis characterized by generalized, continuous shedding of the outer layers of the epidermis. Two main PSS subtypes have been suggested. Patients with non-inflammatory PSS (type A) manifest white scaling, with painless and easy removal of the skin, irritation when in contact with water, dust and sand, and no history of erythema, pruritis or atopy. Inflammatory PSS (type B) is associated with generalized erythema, pruritus and atopy. It is an ichthyosiform erythroderma characterized by lifelong patchy peeling of the entire skin with onset at birth or shortly after. Several patients have been reported with high IgE levels.
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For research use only. Not intended for any clinical use.

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