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Rabbit Anti-CELSR1 Recombinant Antibody (EG639) (CBMAB-EN771-LY)

The product is antibody recognizes CELSR1. The antibody EG639 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:10000.
See all CELSR1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG639
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:10000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human CELSR1.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cadherin EGF LAG Seven-Pass G-Type Receptor 1
Introduction
The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human9620
Mouse12614
Rat300128
UniProt ID
HumanQ9NYQ6
MouseO35161
RatF1MAS4
Alternative Names
Cadherin EGF LAG Seven-Pass G-Type Receptor 1; Adhesion G Protein-Coupled Receptor C1; Cadherin Family Member 9; Flamingo Homolog 2; HFMI2; CDHF9; FMI2; Cadherin, EGF LAG Seven-Pass G-Type Receptor 1, Flamingo (Drosophila) Homolog;
Function
Receptor that may have an important role in cell/cell signaling during nervous system formation.
Biological Process
Apical protein localization Source: UniProtKB
Cell-cell adhesion Source: GO_Central
Central nervous system development Source: UniProtKB
Establishment of body hair planar orientation Source: UniProtKB
Establishment of planar polarity Source: UniProtKB
Establishment of planar polarity of embryonic epithelium Source: UniProtKB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Lateral sprouting involved in lung morphogenesis Source: UniProtKB
Neural tube closure Source: UniProtKB
Neuron migration Source: UniProtKB
Orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: UniProtKB
Planar dichotomous subdivision of terminal units involved in lung branching morphogenesis Source: UniProtKB
Protein localization involved in establishment of planar polarity Source: UniProtKB
Regulation of actin cytoskeleton organization Source: UniProtKB
Rho protein signal transduction Source: UniProtKB
Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL
Cellular Location
Cell membrane
Involvement in disease
Neural tube defects (NTD): Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
Topology
Extracellular: 22-2469
Helical: 2470-2490
Cytoplasmic: 2491-2501
Helical: 2502-2522
Extracellular: 2523-2527
Helical: 2528-2548
Cytoplasmic: 2549-2572
Helical: 2573-2593
Extracellular: 2594-2611
Helical: 2612-2632
Cytoplasmic: 2633-2655
Helical: 2656-2676
Extracellular: 2677-2683
Helical: 2684-2704
Cytoplasmic: 2705-3014
PTM
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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