Human Anti-CELSR3 Recombinant Antibody (CBXC-0932) (CBMAB-C2048-CQ)

This product is a recombinant human antibody that recognizes CELSR3. The antibody CBXC-0932 can be used for immunoassay techniques such as: FC.
See all CELSR3 antibodies

Datasheet

Summary

Host Animal

Human

Specificity

Human

Clone

CBXC-0932

Antibody Isotype

IgG1

Application

Basic Information

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Buffer containing stabilizer

Preservative

0.05% sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Cadherin EGF LAG Seven-Pass G-Type Receptor 3

Introduction

This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation.

Entrez Gene ID

1951

UniProt ID

Q9NYQ7

Alternative Names

Cadherin EGF LAG Seven-Pass G-Type Receptor 3; Multiple Epidermal Growth Factor-Like Domains Protein 2; Adhesion G Protein-Coupled Receptor C3; Epidermal Growth Factor-Like Protein 1; Multiple EGF-Like Domains Protein 2; Cadherin Family Member 11; Flamingo Homolog 1; EGF-Like Protein 1; CDHF11; HFMI1; EGFL1; MEGF2;

Function

Receptor that may have an important role in cell/cell signaling during nervous system formation.

Biological Process

Cell-cell adhesion Source: GO_Central
G protein-coupled receptor signaling pathway Source: GDB
Homophilic cell adhesion via plasma membrane adhesion molecules Source: InterPro
Multicellular organism development Source: UniProtKB-KW
Wnt signaling pathway, planar cell polarity pathway Source: ParkinsonsUK-UCL

Cellular Location

Cell membrane

Topology

Extracellular: 33-2540
Helical: 2541-2561
Cytoplasmic: 2562-2572
Helical: 2573-2593
Extracellular: 2594-2601
Helical: 2602-2622
Cytoplasmic: 2623-2643
Helical: 2644-2664
Extracellular: 2665-2681
Helical: 2682-2702
Cytoplasmic: 2703-2725
Helical: 2726-2746
Extracellular: 2747-2753
Helical: 2754-2774
Cytoplasmic: 2775-3312

References

Sun, Y., Chen, G., He, J., Li, J. X., Gan, X. Y., Ji, S. F., ... & Huang, Z. G. (2021). Clinical Significance and Underlying Mechanisms of CELSR3 in Metastatic Prostate Cancer Based on Immunohistochemistry, Data Mining, and In Silico Analysis. Cancer Biotherapy and Radiopharmaceuticals.

Chen, X., Ma, Q., Liu, Y., Li, H., Liu, Z., Zhang, Z., ... & Shang, Z. (2021). Increased expression of CELSR3 indicates a poor prognostic factor for Prostate Cancer. Journal of Cancer, 12(4), 1115.

Xie, Z., Dang, Y., Wu, H., He, R., Ma, J., Peng, Z., ... & Yang, L. (2020). Effect of CELSR3 on the cell cycle and apoptosis of hepatocellular carcinoma cells. Journal of Cancer, 11(10), 2830.

Ouyang, X., Wang, Z., Yao, L., & Zhang, G. (2020). Elevated CELSR3 expression is associated with hepatocarcinogenesis and poor prognosis. Oncology letters, 20(2), 1083-1092.

Gu, X., Li, H., Sha, L., Mao, Y., Shi, C., & Zhao, W. (2019). CELSR3 mRNA expression is increased in hepatocellular carcinoma and indicates poor prognosis. PeerJ, 7, e7816.

Goffinet, A. M., & Tissir, F. (2017, September). Seven pass cadherins CELSR1-3. In Seminars in cell & developmental biology (Vol. 69, pp. 102-110). Academic Press.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-CELSR3 Recombinant Antibody (2F7)

Mouse Anti-CELSR3 Recombinant Antibody (CBXC-1719)

Mouse Anti-CELSR3 Recombinant Antibody (CBXF-2554)

Rabbit Anti-CELSR3 Recombinant Antibody (EG641)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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