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Rat Anti-CENPN (AA 1-353 ) Recombinant Antibody (CBFYC-1721) (CBMAB-C1783-FY)

This product is rat antibody that recognizes CENPN. The antibody CBFYC-1721 can be used for immunoassay techniques such as: ICC.
See all CENPN antibodies

Summary

Host Animal
Rat
Specificity
Human
Clone
CBFYC-1721
Antibody Isotype
IgG2a
Application
ICC

Basic Information

Immunogen
Full-length Human CENP-N (1-353 aa)
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-353

Target

Full Name
Centromere Protein N
Introduction
The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Entrez Gene ID
55839
UniProt ID
Q96H22
Alternative Names
Centromere Protein N; Interphase Centromere Complex Protein 32; C16orf60; CENP-N; ICEN32; Chromosome 16 Open Reading Frame 60; BM039
Function
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.
Biological Process
CENP-A containing nucleosome assembly Source: Reactome
Chromosome segregation Source: InterPro
Kinetochore assembly Source: InterPro
Mitotic spindle organization Source: Reactome
Cellular Location
Nucleus; Kinetochore. Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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