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Mouse Anti-CENPQ Recombinant Antibody (CBXC-0372) (CBMAB-C5467-CQ)

This product is a mouse antibody that recognizes CENPQ. The antibody CBXC-0372 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all CENPQ antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXC-0372
Antibody Isotype
IgG1, κ
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Centromere Protein Q
Introduction
CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]
Entrez Gene ID
55166
UniProt ID
Q7L2Z9
Alternative Names
Centromere Protein Q; C6orf139; CENP-Q; Chromosome 6 Open Reading Frame 139;
Function
Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420).
Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).
Biological Process
CENP-A containing nucleosome assembly Source: Reactome
Metaphase plate congression Source: UniProtKB
Mitotic spindle organization Source: Reactome
Positive regulation of protein localization to kinetochore Source: UniProtKB
Cellular Location
Nucleus; Centromere. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.
PTM
Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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