CENPQ

CENPQ is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008]

Full Name

Centromere Protein Q

Function

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex (PubMed:16622420).
Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores (PubMed:25395579).

Biological Process

CENP-A containing nucleosome assembly Source: Reactome
Metaphase plate congression Source: UniProtKB
Mitotic spindle organization Source: Reactome
Positive regulation of protein localization to kinetochore Source: UniProtKB

Cellular Location

Nucleus; Centromere. Localizes exclusively in the centromeres. The CENPA-CAD complex is probably recruited on centromeres by the CENPA-NAC complex.

PTM

Phosphorylation at Ser-50 is essential for CENPE recruitment to kinetochores and orderly chromosome congression.