Mouse Anti-CFHR2 Recombinant Antibody (CBYY-C1911) (CBMAB-C3349-YY)

This product is mouse antibody that recognizes CFHR2. The antibody CBYY-C1911 can be used for immunoassay techniques such as: WB, IP
See all CFHR2 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C1911

Antibody Isotype

IgG1

Application

WB, IP

Basic Information

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 2/CFHR2, Glu19-Glu268, Accession # P36980

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Protein A/G purified

Buffer

LYOPH

Preservative

PBS

Concentration

Lyophilized

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Complement Factor H Related 2

Entrez Gene ID

3080

UniProt ID

P36980

Alternative Names

Chorionic Gonadotropin Beta Subunit 2; Chorionic Gonadotropin, Beta Polypeptide 2;

Function

Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

Biological Process

Cytolysis by host of symbiont cells Source: UniProtKB
Negative regulation of protein binding Source: UniProtKB
Regulation of complement activation Source: Reactome

Cellular Location

Secreted

PTM

N-glycosylated.

References

Lorés-Motta, L., van Beek, A. E., Willems, E., Zandstra, J., van Mierlo, G., Einhaus, A., ... & den Hollander, A. I. (2021). Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration. The American Journal of Human Genetics, 108(8), 1367-1384.

Qi, P., Wu, B., Guo, B., Zhang, C., & Xu, K. (2018). The complement factor H (CFH) and its related protein 2 (CFHR2) mediating immune response in large yellow croaker Larimichthys crocea. Developmental & Comparative Immunology, 84, 241-249.

van Beek, A. E., Pouw, R. B., Brouwer, M. C., van Mierlo, G., Geissler, J., Ooijevaar-de Heer, P., ... & Kuijpers, T. W. (2017). Factor H-related (FHR)-1 and FHR-2 form homo-and heterodimers, while FHR-5 circulates only as homodimer in human plasma. Frontiers in immunology, 8, 1328.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Antibody Pairs

CFHR2 Matched Antibody Pair (266)

Related Products

CFHR2 Matched Antibody Pair (266)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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