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Mouse Anti-CHN1 Recombinant Antibody ( 1B7) (CBMAB-0239CQ)

This product is a mouse antibody that recognizes CHN1. The antibody 1B7 can be used for immunoassay techniques such as: WB, IHC-P.
See all CHN1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1B7
Antibody Isotype
IgG1
Application
WB, IHC-P

Basic Information

Immunogen
Full length human recombinant protein of human CHN1
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Chimerin 1
Introduction
This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor, a 34-kD protein. They found that the N-terminal half shared almost 50% identity with sequences in the regulatory domain of protein kinase C (176960); the C-terminal half had 42% identity with the C-terminal region of BCR, the product of the breakpoint cluster region gene involved in the Philadelphia chromosome translocation. By Western blot analysis of mouse hippocampal lysates, Buttery et al. (2006) found alpha-1-chimerin levels slowly increased during the first 2 weeks of postnatal development. Highest expression was in neurons of the hippocampus and cortex, as well as Purkinje cells in the cerebellum.
Entrez Gene ID
1123
UniProt ID
P15882
Alternative Names
Chimerin 1; Rho GTPase-Activating Protein 2; Chimerin (Chimaerin) 1; Alpha-Chimerin; Chimaerin 1; A-Chimaerin; N-Chimerin; ARHGAP2; CHN; NC; Chimerin 1 (GTPase-Activating Protein; Duane Retraction Syndrome 2; A2-Chimaerin; RhoGAP2; DURS2; Rho; 2)
Function
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Biological Process
Ephrin receptor signaling pathway Source: UniProtKB
Intracellular signal transduction Source: InterPro
Motor neuron axon guidance Source: UniProtKB
Regulation of axonogenesis Source: UniProtKB
Regulation of GTPase activity Source: GO_Central
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Cytosol
Involvement in disease
Duane retraction syndrome 2 (DURS2): A form of Duane retraction syndrome, a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction or both, narrowing of the palpebral fissure, and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
PTM
Phosphorylated. Phosphorylation is EPHA4 kinase activity-dependent (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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