CHN1

This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Full Name
Chimerin 1
Function
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
Biological Process
Ephrin receptor signaling pathway Source: UniProtKB
Intracellular signal transduction Source: InterPro
Motor neuron axon guidance Source: UniProtKB
Regulation of axonogenesis Source: UniProtKB
Regulation of GTPase activity Source: GO_Central
Regulation of small GTPase mediated signal transduction Source: Reactome
Cellular Location
Cytosol
Involvement in disease
Duane retraction syndrome 2 (DURS2): A form of Duane retraction syndrome, a congenital eye movement disorder characterized by a failure of cranial nerve VI (the abducens nerve) to develop normally, resulting in restriction or absence of abduction, adduction or both, narrowing of the palpebral fissure, and retraction of the globe on attempted adduction. Undiagnosed in children, it can lead to amblyopia, a permanent uncorrectable loss of vision.
PTM
Phosphorylated. Phosphorylation is EPHA4 kinase activity-dependent (By similarity).
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Anti-CHN1 antibodies

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Mouse Anti-CHN1 Recombinant Antibody (CBFYC-1843) (CBMAB-C1907-FY)

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Target: CHN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1843
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-CHN1 Recombinant Antibody (4D1) (CBMAB-C6759-LY)

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Target: CHN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 4D1
Application*: WB
Datasheet SDS

Mouse Anti-CHN1 Recombinant Antibody (3F8) (CBMAB-C6071-LY)

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Target: CHN1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 3F8
Application*: E, WB
Datasheet SDS

Mouse Anti-CHN1 Recombinant Antibody (3A3) (CBMAB-C5643-LY)

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Target: CHN1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 3A3
Application*: E, WB
Datasheet SDS

Mouse Anti-CHN1 Recombinant Antibody (2A1) (CBMAB-C4564-LY)

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Target: CHN1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: 2A1
Application*: WB
Datasheet SDS

Human Recombinant CHN1 protein, GST Tag (V2LY-0526-LY3125)

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Target: CHN1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 2-459
Tag: GST Tag
Datasheet SDS

Human Recombinant CHN1 protein (V2LY-0526-LY3124)

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Target: CHN1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 2-459
Datasheet SDS

CHN1 Matched Antibody Pair (270) (APMAB-270LY)

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Target: CHN1
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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