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Rat Anti-CHRNA4 Recombinant Antibody (CBWJN-1065) (CBMAB-N0669-WJ)

This product is a Rat antibody that recognizes CHRNA4. The antibody CBWJN-1065 can be used for immunoassay techniques such as: WB, IP, ICC.
See all CHRNA4 antibodies

Summary

Host Animal
Rat
Specificity
Mouse, Rat, Chicken, Human
Clone
CBWJN-1065
Antibody Isotype
IgG1
Application
WB, IP, ICC

Basic Information

Specificity
Mouse, Rat, Chicken, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
cholinergic receptor, nicotinic, alpha 4
Introduction
This gene encodes a nicotinic acetylcholine receptor, which belongs to a superfamily of ligand-gated ion channels that play a role in fast signal transmission at synapses. These pentameric receptors can bind acetylcholine, which causes an extensive change in conformation that leads to the opening of an ion-conducting channel across the plasma membrane. This protein is an integral membrane receptor subunit that can interact with either nAChR beta-2 or nAChR beta-4 to form a functional receptor. Mutations in this gene cause nocturnal frontal lobe epilepsy type 1. Polymorphisms in this gene that provide protection against nicotine addiction have been described. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Entrez Gene ID
Human1137
Mouse11438
Rat25590
Chicken395606
UniProt ID
HumanP43681
MouseO70174
RatP09483
ChickenP09482
Alternative Names
Cholinergic Receptor Nicotinic Alpha 4 Subunit; Cholinergic Receptor, Nicotinic, Alpha Polypeptide 4; Cholinergic Receptor, Nicotinic, Alpha 4 (Neuronal); Cholinergic Receptor, Nicotinic Alpha 4; NACRA4; Neuronal Nicotinic Acetylcholine Receptor Alpha-4 Subunit; Acetylcholine Receptor, Nicotinic, Alpha 4 (Neuronal);
Function
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions.
Biological Process
Action potential Source: UniProtKB
B cell activation Source: UniProtKB
Behavioral response to nicotine Source: UniProtKB
Calcium ion transport Source: UniProtKB
Chemical synaptic transmission Source: GO_Central
Cognition Source: UniProtKB
DNA repair Source: UniProtKB
Inhibitory postsynaptic potential Source: UniProtKB
Ion transmembrane transport Source: GO_Central
Ion transport Source: UniProtKB
Membrane depolarization Source: UniProtKB
Nervous system process Source: UniProtKB
Regulation of dopamine secretion Source: UniProtKB
Regulation of membrane potential Source: UniProtKB
Response to hypoxia Source: UniProtKB
Response to nicotine Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Sensory perception of pain Source: UniProtKB
Signal transduction Source: UniProtKB
Synaptic transmission, cholinergic Source: UniProtKB
Cellular Location
Postsynaptic cell membrane; Cell membrane
Involvement in disease
Epilepsy, nocturnal frontal lobe, 1 (ENFL1): An autosomal dominant focal epilepsy characterized by nocturnal seizures with hyperkinetic automatisms and poorly organized stereotyped movements.
Topology
Extracellular: 29-242
Helical: 243-267
Helical: 275-293
Helical: 309-330
Cytoplasmic: 331-600
Helical: 601-619
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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