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Rabbit Anti-CKS1B Recombinant Antibody (EG713) (CBMAB-EN867-LY)

The product is antibody recognizes CKS1. The antibody EG713 immunoassay techniques such as: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000.
See all CKS1B antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
EG713
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from N-terminal of human CKS1.
Specificity
Human, Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CDC28 protein kinase regulatory subunit 1B
Entrez Gene ID
Human1163
Mouse54124
UniProt ID
HumanP61024
MouseP61025
Function
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Biological Process
Cell division Source: UniProtKB-KW
Cell population proliferation Source: Ensembl
Mitotic cell cycle phase transition Source: Ensembl
Regulation of mitotic cell cycle Source: GO_Central
Regulation of transcription, DNA-templated Source: Ensembl
Cellular Location
Nucleoplasm; Cyclin-dependent protein kinase holoenzyme complex; SCF ubiquitin ligase complex

Mo, C., Xie, L., Chen, C., Ma, J., Huang, Y., Wu, Y., ... & Mao, R. (2021). The Clinical Significance and Potential Molecular Mechanism of Upregulated CDC28 Protein Kinase Regulatory Subunit 1B in Osteosarcoma. Journal of oncology, 2021.

Mamoor, S. (2021). Differential expression of CDC28 protein kinase regulatory subunit 1B in triple negative breast cancer.

Ahsan, A., Polonskaia, A., Hsu, C. C., Bjorklund, C. C., Estevez, M. O., Towfic, F., ... & Thakurta, A. (2021). Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination. Blood, 138, 2658.

Jia, Y., Tian, Q., Yang, K., Liu, Y., & Liu, Y. (2021). A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors. BioMed research international, 2021.

Wang, X., Tao, G., Huang, D., Liang, S., & Zheng, D. (2020). Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA‑485‑5p/CKS1B axis. Oncology reports, 44(5), 2009-2020.

Zeng, Z., Gao, Z. L., Zhang, Z. P., Jiang, H. B., Yang, C. Q., Yang, J., & Xia, X. B. (2019). Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway. International journal of molecular medicine, 44(1), 103-114.

Liu, Y., Wang, W., Li, Y., Sun, F., Lin, J., & Li, L. (2018). CKS1BP7, a Pseudogene of CKS1B, is Co-Amplified with IGF1R in Breast Cancers. Pathology & Oncology Research, 24(2), 223-229.

Wang, H., Sun, M., Guo, J., Ma, L., Jiang, H., Gu, L., ... & Zhou, Y. (2017). 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways. Biochemical pharmacology, 135, 35-49.

Shi, G., Zhao, C., Fu, M., & Qiu, L. (2017). Molecular cloning and expression analysis of the CKS 1B gene from black tiger shrimps (Penaeus monodon). Aquaculture Research, 48(9), 5133-5138.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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