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Mouse Anti-CKS1B Recombinant Antibody (CBYY-C3179) (CBMAB-C4622-YY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBYY-C3179
Antibody Isotype
IgG1, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Synthetic peptide derived from the C-terminal region of the human Cks1 protein.
Host Species
Mouse
Specificity
Human, Mouse
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.1% sodium azide
Concentration
0.5 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CDC28 protein kinase regulatory subunit 1B
Entrez Gene ID
1163
UniProt ID
P61024
Function
Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.
Biological Process
Cell division Source: UniProtKB-KW
Cell population proliferation Source: Ensembl
Mitotic cell cycle phase transition Source: Ensembl
Regulation of mitotic cell cycle Source: GO_Central
Regulation of transcription, DNA-templated Source: Ensembl
Cellular Location
Nucleoplasm; Cyclin-dependent protein kinase holoenzyme complex; SCF ubiquitin ligase complex
More Infomation

Mo, C., Xie, L., Chen, C., Ma, J., Huang, Y., Wu, Y., ... & Mao, R. (2021). The Clinical Significance and Potential Molecular Mechanism of Upregulated CDC28 Protein Kinase Regulatory Subunit 1B in Osteosarcoma. Journal of oncology, 2021.

Mamoor, S. (2021). Differential expression of CDC28 protein kinase regulatory subunit 1B in triple negative breast cancer.

Ahsan, A., Polonskaia, A., Hsu, C. C., Bjorklund, C. C., Estevez, M. O., Towfic, F., ... & Thakurta, A. (2021). Super-Enhancer Driven Regulation of CKS1B in Multiple Myeloma: Implications in Mediating Response to BET Inhibitor and Celmod Agent Combination. Blood, 138, 2658.

Jia, Y., Tian, Q., Yang, K., Liu, Y., & Liu, Y. (2021). A Pan-Cancer Analysis of Clinical Prognosis and Immune Infiltration of CKS1B in Human Tumors. BioMed research international, 2021.

Wang, X., Tao, G., Huang, D., Liang, S., & Zheng, D. (2020). Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA‑485‑5p/CKS1B axis. Oncology reports, 44(5), 2009-2020.

Zeng, Z., Gao, Z. L., Zhang, Z. P., Jiang, H. B., Yang, C. Q., Yang, J., & Xia, X. B. (2019). Downregulation of CKS1B restrains the proliferation, migration, invasion and angiogenesis of retinoblastoma cells through the MEK/ERK signaling pathway. International journal of molecular medicine, 44(1), 103-114.

Liu, Y., Wang, W., Li, Y., Sun, F., Lin, J., & Li, L. (2018). CKS1BP7, a Pseudogene of CKS1B, is Co-Amplified with IGF1R in Breast Cancers. Pathology & Oncology Research, 24(2), 223-229.

Wang, H., Sun, M., Guo, J., Ma, L., Jiang, H., Gu, L., ... & Zhou, Y. (2017). 3-O-(Z)-coumaroyloleanolic acid overcomes Cks1b-induced chemoresistance in lung cancer by inhibiting Hsp90 and MEK pathways. Biochemical pharmacology, 135, 35-49.

Shi, G., Zhao, C., Fu, M., & Qiu, L. (2017). Molecular cloning and expression analysis of the CKS 1B gene from black tiger shrimps (Penaeus monodon). Aquaculture Research, 48(9), 5133-5138.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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