Mouse Anti-CLEC11A Recombinant Antibody (CBYY-C3145) (CBMAB-C4588-YY)

This product is mouse antibody that recognizes CLEC11A. The antibody CBYY-C3145 can be used for immunoassay techniques such as: ELISA
See all CLEC11A antibodies

Summary

Host Animal

Mouse

Specificity

Human

Clone

CBYY-C3145

Antibody Isotype

IgG2b, λ

Application

ELISA

Basic Information

Immunogen

CLEC11A (NP_002966, 214 a.a. ~ 323 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa

Specificity

Human

Antibody Isotype

IgG2b, λ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Preservative

PBS

Concentration

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

C-Type Lectin Domain Containing 11A

Entrez Gene ID

6320

UniProt ID

Q9Y240

Function

Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts (PubMed:27976999).

Important for repair and maintenance of adult bone (By similarity).

Biological Process

Ossification Source: GO_Central
Positive regulation of cell population proliferation Source: UniProtKB

Cellular Location

Secreted; Cytoplasm

PTM

O-glycosylated. Probably sulfated on the O-glycans.

References

Yin, C., Zhang, J., Guan, W., Dou, L., Liu, Y., Shen, M., ... & Li, Y. (2021). High expression of CLEC11A predicts favorable prognosis in acute myeloid leukemia. Frontiers in Oncology, 11, 22.

Wang, M., Guo, J., Zhang, L., Kuek, V., Xu, J., & Zou, J. (2020). Molecular structure, expression, and functional role of Clec11a in skeletal biology and cancers. Journal of cellular physiology, 235(10), 6357-6365.

Hu, Y., Zhang, Y., Ni, C. Y., Chen, C. Y., Rao, S. S., Yin, H., ... & Xie, H. (2020). Human umbilical cord mesenchymal stromal cells-derived extracellular vesicles exert potent bone protective effects by CLEC11A-mediated regulation of bone metabolism. Theranostics, 10(5), 2293.

Chaboya, C. (2019). Elucidating the signaling pathways for the c-type lectin clec11a in human mesenchymal stromal cells.

Shi, R., Hu, J., Li, W., Wang, Z., Pan, Y., Bai, M., ... & Zhao, S. (2019). Protective effects of Clec11a in islets against lipotoxicity via modulation of proliferation and lipid metabolism in mice. Experimental cell research, 384(1), 111613.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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