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Rabbit Anti-CLEC14A Recombinant Antibody (CBFYC-1912) (CBMAB-C1977-FY)

This product is rabbit antibody that recognizes CLEC14A. The antibody CBFYC-1912 can be used for immunoassay techniques such as: ELISA.
See all CLEC14A antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBFYC-1912
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse CLEC14A protein
Specificity
Mouse
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
C-Type Lectin Domain Containing 14A
Introduction
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.
Entrez Gene ID
66864
UniProt ID
Q8VCP9
Alternative Names
AI642649; 1200003C23Rik
Biological Process
Cell migration Source: GO_Central
Cell migration involved in sprouting angiogenesis Source: Ensembl
Lymphangiogenesis Source: Ensembl
Vascular endothelial growth factor receptor-2 signaling pathway Source: GO_Central
Vascular endothelial growth factor receptor-3 signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 22-397
Helical: 398-418
Cytoplasmic: 419-490

Qiao, C., Qiu, Y., Zou, Y., Hua, C., Li, Y., Jin, Y., & Lin, X. (2021). Bleomycin inhibits CLEC14A to attenuate the progression of extracranial arteriovenous malformations. Chinese Journal of Plastic and Reconstructive Surgery.

Sandoval, D. R., Toledo, A. G., Painter, C. D., Tota, E. M., Sheikh, M. O., West, A. M., ... & Esko, J. D. (2020). Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein. Journal of Biological Chemistry, 295(9), 2804-2821.

Kim, Y., Lee, S., Zhang, H., Lee, S., Kim, H., Kim, Y., ... & Kwon, Y. G. (2020). CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation. Journal of neuroinflammation, 17(1), 1-14.

Bocci, M., Sjölund, J., Kurzejamska, E., Lindgren, D., Marzouka, N. A. D., Bartoschek, M., ... & Pietras, K. (2019). Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer. Angiogenesis, 22(1), 117-131.

Kim, T. K., Park, C. S., Jang, J., Kim, M. R., Na, H. J., Lee, K., ... & Lee, S. (2018). Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC 14a. Molecular oncology, 12(3), 356-372.

Priya, S. K., Kumar, K., Hiran, K. R., Bindhu, M. R., Nagare, R. P., Vijaykumar, D. K., & Ganesan, T. S. (2017). Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance. International journal of clinical oncology, 22(1), 107-117.

Jang, J., Kim, M. R., Kim, T. K., Lee, W. R., Kim, J. H., Heo, K., & Lee, S. (2017). CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis. Scientific reports, 7(1), 1-12.

Lee, S., Rho, S. S., Park, H., Park, J. A., Kim, J., Lee, I. K., ... & Kwon, Y. G. (2017). Carbohydrate-binding protein CLEC14A regulates VEGFR-2–and VEGFR-3–dependent signals during angiogenesis and lymphangiogenesis. The Journal of clinical investigation, 127(2), 457-471.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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