CLEC14A

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. This family member plays a role in cell-cell adhesion and angiogenesis. It functions in filopodia formation, cell migration and tube formation. Due to its presence at higher levels in tumor endothelium than in normal tissue endothelium, it is considered to be a candidate for tumor vascular targeting.

C-Type Lectin Domain Containing 14A

Cell migration Source: GO_Central
Cell migration involved in sprouting angiogenesis Source: Ensembl
Lymphangiogenesis Source: Ensembl
Vascular endothelial growth factor receptor-2 signaling pathway Source: GO_Central
Vascular endothelial growth factor receptor-3 signaling pathway Source: GO_Central

Membrane

Extracellular: 22-397
Helical: 398-418
Cytoplasmic: 419-490