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Rabbit Anti-CLEC14A Recombinant Antibody (CBFYC-1912) (V2LY-1206-LY90)


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Summary

Host Animal
Rabbit
Specificity
Mouse
Clone
CBFYC-1912
Antibody Isotype
IgG
Application
ELISA

Basic Information

Immunogen
Recombinant Mouse CLEC14A protein.
Host Species
Rabbit
Specificity
Mouse
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:5,000-1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
C-Type Lectin Domain Containing 14A
Entrez Gene ID
66864
UniProt ID
Q8VCP9
Biological Process
Cell migration Source: GO_Central
Cell migration involved in sprouting angiogenesis Source: Ensembl
Lymphangiogenesis Source: Ensembl
Vascular endothelial growth factor receptor-2 signaling pathway Source: GO_Central
Vascular endothelial growth factor receptor-3 signaling pathway Source: GO_Central
Cellular Location
Membrane
Topology
Extracellular: 22-397
Helical: 398-418
Cytoplasmic: 419-490
More Infomation

Qiao, C., Qiu, Y., Zou, Y., Hua, C., Li, Y., Jin, Y., & Lin, X. (2021). Bleomycin inhibits CLEC14A to attenuate the progression of extracranial arteriovenous malformations. Chinese Journal of Plastic and Reconstructive Surgery.

Sandoval, D. R., Toledo, A. G., Painter, C. D., Tota, E. M., Sheikh, M. O., West, A. M., ... & Esko, J. D. (2020). Proteomics-based screening of the endothelial heparan sulfate interactome reveals that C-type lectin 14a (CLEC14A) is a heparin-binding protein. Journal of Biological Chemistry, 295(9), 2804-2821.

Kim, Y., Lee, S., Zhang, H., Lee, S., Kim, H., Kim, Y., ... & Kwon, Y. G. (2020). CLEC14A deficiency exacerbates neuronal loss by increasing blood-brain barrier permeability and inflammation. Journal of neuroinflammation, 17(1), 1-14.

Bocci, M., Sjölund, J., Kurzejamska, E., Lindgren, D., Marzouka, N. A. D., Bartoschek, M., ... & Pietras, K. (2019). Activin receptor-like kinase 1 is associated with immune cell infiltration and regulates CLEC14A transcription in cancer. Angiogenesis, 22(1), 117-131.

Kim, T. K., Park, C. S., Jang, J., Kim, M. R., Na, H. J., Lee, K., ... & Lee, S. (2018). Inhibition of VEGF‐dependent angiogenesis and tumor angiogenesis by an optimized antibody targeting CLEC 14a. Molecular oncology, 12(3), 356-372.

Priya, S. K., Kumar, K., Hiran, K. R., Bindhu, M. R., Nagare, R. P., Vijaykumar, D. K., & Ganesan, T. S. (2017). Expression of a novel endothelial marker, C-type lectin 14A, in epithelial ovarian cancer and its prognostic significance. International journal of clinical oncology, 22(1), 107-117.

Jang, J., Kim, M. R., Kim, T. K., Lee, W. R., Kim, J. H., Heo, K., & Lee, S. (2017). CLEC14a-HSP70-1A interaction regulates HSP70-1A-induced angiogenesis. Scientific reports, 7(1), 1-12.

Lee, S., Rho, S. S., Park, H., Park, J. A., Kim, J., Lee, I. K., ... & Kwon, Y. G. (2017). Carbohydrate-binding protein CLEC14A regulates VEGFR-2–and VEGFR-3–dependent signals during angiogenesis and lymphangiogenesis. The Journal of clinical investigation, 127(2), 457-471.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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