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Recombinant Rabbit Anti-CNN1 Antibody (CBAb073) (CBMAB-Ab073-LY)

The product is antibody recognizes CNN1. The antibody CBAb073 immunoassay techniques such as: WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200.
See all CNN1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Dog, Pig
Clone
CBAb073
Antibody Isotype
IgG
Application
WB 1:500-1:2000; IHC 1:50-1:200; IF 1:50-1:200

Basic Information

Immunogen
Recombinant protein of human CNN1
Specificity
Human, Mouse, Rat, Dog, Pig
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Calponin 1
Entrez Gene ID
Human1264
Mouse12797
Rat65204
Dog484937
Pig396911
UniProt ID
HumanP51911
MouseQ08091
RatQ08290
DogE2RB32
PigQ08092
Alternative Names
CNN1; HEL-S-14; SMCC; Sm-Calp; calponin-1
Function
Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity (By similarity).
Biological Process
Actomyosin structure organization Source: InterPro
Negative regulation of vascular associated smooth muscle cell proliferation Source: BHF-UCL
Regulation of smooth muscle contraction Source: UniProtKB
Cellular Location
Cytoskeleton; Focal adhesion

Choo, Y. Y., Sakai, T., Komatsu, S., Ikebe, R., Jeffers, A., Singh, K. P., ... & Ikebe, M. (2022). Calponin 1 contributes to myofibroblast differentiation of human pleural mesothelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology.

Mamoor, S. (2021). Differential expression of calponin 1 in cancers of the breast.

Liu, W., Fu, X., & Li, R. (2021). CNN1 regulates the DKK1/Wnt/β‑catenin/c‑myc signaling pathway by activating TIMP2 to inhibit the invasion, migration and EMT of lung squamous cell carcinoma cells. Experimental and therapeutic medicine, 22(2), 1-9.

Wang, Z., Li, T. E., Chen, M., Pan, J. J., & Shen, K. W. (2020). miR-106b-5p contributes to the lung metastasis of breast cancer via targeting CNN1 and regulating Rho/ROCK1 pathway. Aging (Albany NY), 12(2), 1867.

Feng, H. Z., Wang, H., Takahashi, K., & Jin, J. P. (2019). Double deletion of calponin 1 and calponin 2 in mice decreases systemic blood pressure with blunted length-tension response of aortic smooth muscle. Journal of molecular and cellular cardiology, 129, 49-57.

Zhao, H., Yang, K., Liu, Q., Hu, J., Wu, W., & Wang, J. (2019). Expression of calponin-1 and its pathogenic role in systemic sclerosis. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 39(3), 279-285.

Cetin, O., Karaman, E., Boza, B., Cim, N., & Sahin, H. G. (2018). Maternal serum calponin 1 level as a biomarker for the short-term prediction of preterm birth in women with threatened preterm labor. The Journal of Maternal-Fetal & Neonatal Medicine, 31(2), 216-222.

Xu, H., Wu, F., Zhang, H., Yang, C., Li, K., Wang, H., ... & Dai, Z. (2017). Actin cytoskeleton mediates BMP2-Smad signaling via calponin 1 in preosteoblast under simulated microgravity. Biochimie, 138, 184-193.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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