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Mouse Anti-CNOT7 Recombinant Antibody (2C4) (CBMAB-C4786-LY)

This product is antibody recognizes CNOT7. The antibody 2C4 immunoassay techniques such as: ELISA.
See all CNOT7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2C4
Antibody Isotype
IgG1, κ
Application
ELISA

Basic Information

Immunogen
CNOT7 (AAH60852, 1 a.a. ~ 285 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: MPAATVDHSQ RICEVWACNL DEEMKKIRQV IRKYNYVAMD TEFPGVVARP IGEFRSNADY QYQLLRCNVD LLKIIQLGLT FMNEQGEYPP GTSTWQFNFK FNLTEDMYAQ
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CCR4-NOT Transcription Complex Subunit 7
Introduction
CNOT6 (CCR4-NOT Transcription Complex Subunit 6) is a Protein Coding gene. Among its related pathways are Gene Expression and Deadenylation-dependent mRNA decay. Gene Ontology (GO) annotations related to this gene include RNA binding and poly(A)-specific ribonuclease activity. An important paralog of this gene is CNOT6L.
Entrez Gene ID
29883
UniProt ID
Q9UIV1
Alternative Names
CCR4-NOT Transcription Complex Subunit 7; CCR4-Associated Factor 1; BTG1-Binding Factor 1; CAF-1; CAF1A; CAF1;
Function
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
Biological Process
Deadenylation-dependent decapping of nuclear-transcribed mRNA Source: Ensembl
Defense response to virus Source: UniProtKB
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Source: Reactome
Exonucleolytic catabolism of deadenylated mRNA Source: UniProtKB
Gene silencing by miRNA Source: UniProtKB
Gene silencing by RNA Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of gene expression Source: BHF-UCL
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of translation Source: GO_Central
Negative regulation of type I interferon-mediated signaling pathway Source: UniProtKB
Nuclear-transcribed mRNA poly(A) tail shortening Source: Reactome
P-body assembly Source: Ensembl
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of mRNA catabolic process Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay Source: UniProtKB
Positive regulation of nuclear-transcribed mRNA poly(A) tail shortening Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of viral genome replication Source: UniProtKB
Regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Cellular Location
Nucleus; P-body. NANOS2 promotes its localization to P-body.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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